Protein Info for CA264_05070 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: indole-3-glycerol phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 48% identical to TRPC_BACTN: Indole-3-glycerol phosphate synthase (trpC) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K01609, indole-3-glycerol phosphate synthase [EC: 4.1.1.48] (inferred from 53% identity to mtt:Ftrac_1041)

Predicted SEED Role

"Indole-3-glycerol phosphate synthase (EC 4.1.1.48)" in subsystem Tryptophan synthesis (EC 4.1.1.48)

MetaCyc Pathways

superpathway of aromatic amino acid biosynthesis (17/18 steps found)
superpathway of L-tryptophan biosynthesis (13/13 steps found)
L-tryptophan biosynthesis (6/6 steps found)
superpathway of chorismate metabolism (39/59 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.48

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YPQ3 at UniProt or InterPro

Protein Sequence (272 amino acids)

>CA264_05070 indole-3-glycerol phosphate synthase (Pontibacter actiniarum KMM 6156, DSM 19842)
MNILDEIIANKYKEVAERKELYPVKLLEKSLYFETPCISLERYLLRPDKTGIIAEIKRKS
PSKGDINPYVSVERTSIGYMQAGASALSVLTDGPYFGGKNEDLLTARKYNYCPILRKDFT
VDEYQIVEAKSIGADAILLIAAALEPAHLKQLAAFARSFGLEVLLEVRDKEELANTLSED
VNVVGVNNRNLKDFVTDVNASYEIARHIPAGVTKISESGISNPKTMVELKEAGFNGFLIG
ETFMHNSRPEQAAANFIREYKQLLERKTASLV