Protein Info for CA264_04965 in Pontibacter actiniarum KMM 6156, DSM 19842
Annotation: dihydrofolate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K11754, dihydrofolate synthase / folylpolyglutamate synthase [EC: 6.3.2.12 6.3.2.17] (inferred from 52% identity to phe:Phep_1166)Predicted SEED Role
No annotation
MetaCyc Pathways
- superpathway of tetrahydrofolate biosynthesis and salvage (10/12 steps found)
- tetrahydrofolate biosynthesis I (3/3 steps found)
- superpathway of tetrahydrofolate biosynthesis (8/10 steps found)
- folate polyglutamylation (4/5 steps found)
- tetrahydrofolate biosynthesis II (2/3 steps found)
- superpathway of chorismate metabolism (39/59 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.3.2.12 or 6.3.2.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9YPM7 at UniProt or InterPro
Protein Sequence (431 amino acids)
>CA264_04965 dihydrofolate synthase (Pontibacter actiniarum KMM 6156, DSM 19842) MTYQECLDYLYQQLPMYQRIGNAAFKKSLDNITALCEALGQPHQQFKSVHVAGTNGKGSS SHMLAAVLQEAGYKTGLYTSPHLKSFTERVRVNGQELPQEYLIRFVAKHKALFERVKPSF FEMTVALAFQYFAEEQVDVAVIEVGLGGRLDSTNIITPELSLITNISYDHQSMLGDTLGA IAAEKAGIIKPNVPVVISTRQQEAEEVFVAKAAEVGAGLYFAPDHFRLERTDSDLQRQVF QVYCDEALYLQGLELDLSGVYQKYNLPGVLQALAVLQEQKGYVVPESAVRKGLAHTKRIT GLKGRWQVLQQAPLTICDTGHNEDGVKQILQGLEVLQPKQVHMVFGAVNDKDVIKILQLL PQTYAYYFCQADIPRALPVQELLQKAASVGLQGEGYATVASALAAARANAAPDEVIFIGG STFVVAEIDEL