Protein Info for CA264_03795 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: 3-deoxy-manno-octulosonate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 244 TIGR00466: 3-deoxy-D-manno-octulosonate cytidylyltransferase" amino acids 4 to 238 (235 residues), 247.9 bits, see alignment E=4.8e-78 PF02348: CTP_transf_3" amino acids 5 to 219 (215 residues), 211.4 bits, see alignment E=1.5e-66 PF12804: NTP_transf_3" amino acids 13 to 129 (117 residues), 40.8 bits, see alignment E=2.6e-14

Best Hits

Swiss-Prot: 60% identical to KDSB_PARD8: 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K00979, 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC: 2.7.7.38] (inferred from 64% identity to phe:Phep_2582)

Predicted SEED Role

"3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38)" in subsystem KDO2-Lipid A biosynthesis (EC 2.7.7.38)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YP32 at UniProt or InterPro

Protein Sequence (244 amino acids)

>CA264_03795 3-deoxy-manno-octulosonate cytidylyltransferase (Pontibacter actiniarum KMM 6156, DSM 19842)
MEVLGIIPARYASTRFPGKPLTDIKGKTMIQRVYEQAKQSGLAEVLVATDDERIREHVQS
FGGKAVMTGTEHQSGTDRCFEAYKRHDQPYEYIINIQGDEPFIHPEQIDLVARCFEHPHT
QLATLIKKIETPEELFNINAPKVVISQHGEALYFSRQPIPYCRNIPNDIWHKQHTYYKHI
GIYGYRADILEQITQLPPSSLELAESLEQLRWLENGFRITTALTHHETIGIDTPEDLQRI
VDKA