Protein Info for CA264_03175 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: acriflavin resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1061 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 333 to 353 (21 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 463 to 486 (24 residues), see Phobius details amino acids 531 to 553 (23 residues), see Phobius details amino acids 860 to 882 (23 residues), see Phobius details amino acids 889 to 908 (20 residues), see Phobius details amino acids 914 to 936 (23 residues), see Phobius details amino acids 963 to 981 (19 residues), see Phobius details amino acids 992 to 1018 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1019 (1016 residues), 888.4 bits, see alignment E=9e-271 PF03176: MMPL" amino acids 256 to 493 (238 residues), 40 bits, see alignment E=3.7e-14 PF02355: SecD_SecF" amino acids 327 to 484 (158 residues), 20.7 bits, see alignment E=3.7e-08

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 59% identity to lby:Lbys_3121)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YNT1 at UniProt or InterPro

Protein Sequence (1061 amino acids)

>CA264_03175 acriflavin resistance protein (Pontibacter actiniarum KMM 6156, DSM 19842)
MNITKISIQRSTIVVVIFAILTLLGLASYFSLNYELLPKFSPPVLTVSTFYPGASPSEVE
NSVTKEIEDALSSLENVDEVKSTSQESFSVIVIQLKQGTDVDQSLQDAQRKINAILGELP
EDADPPSLGKFDFSDMPIMQVGATAKMSPTAFYDLIENKVKPELSRVPGMAQIKVLGGQE
REIKVNLDADRLQAYGLSISQVQQKIQYSNLDFPTGKVKNEEGQTLIRLAGKYETVDQLR
NLVLKEDATGASVRLSDVAEVQDAQKDVEVLTRVNSLSSIGLSIQKQSDANAVEVSELTR
KALDQLEETYAAEGLSFTVAKDSSEFTLEAADAVIHDLFLAIVLVAVVMLLFLHSLRNAV
IVMISIPASLIATFIAMNLLGYSLNLMTLLGLSLVVGILVDDAIVVIENIYRHMEMGKKP
AQAAYDGIREIMATVTSITLVIVVVFVPIALSTGLVSDILRQFSVVVAISTMLSLFVAFT
LIPLLASRFSRLEHLSDKNFFGRFILSFERFLDRVIDGFTAALKWAFNHKFITMAATVVL
LVASIALVPAGFIGSEFVSAGDRGEFIVQLELPKNATVEQTNFAARQVEGYLEQYPEVTN
LFTTVGTTSSAQAGQNTAYMAEVNVQLVDATERVLSTNAFSREMKVGLEETIPGVKITMV
PVSMVGGGNQSPIQVIMTGSNLDTLMAFSDRVMAEVEQVQGTAEVKKSVEDGNPEIAVSV
DRDKMASLGLSLEQVGAGMQTAFSGNTNAQFRGSERDYDINIRLDDFDRRNTADIGNLAF
TNNKGEQIRLSQFANIEQSSGPSKLERKDRVSSVSVNSQVIGRPTGSVGTEIQERLANMD
TPNGVSIAYGGDLKNQSEGFGTLGLALMASIVFVYLIMVALYDSYVYPLVVLFSIPLAII
GALLALALSASTLSIFSILGIIMLIGLVAKNAIMVVDFTNNLKSEGVEVKEALIEAVRIR
FRPILMTTLAMVIGMLPIALASGPGAEWKNGLAWALIGGLSSSMFLTLIVVPVIYYLFDR
IMAKLGMDKKTVIELEDKSMEELERETAELENNKMSHSHAY