Protein Info for CA264_02970 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: glucose-1-phosphate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02623: glucose-1-phosphate cytidylyltransferase
  • amino acids 1 to 258 (258 residues), 455.3 bits, E=2.9e-141
• PF00483: NTP_transferase
  • amino acids 2 to 204 (203 residues), 72.7 bits, E=3.6e-24
• PF12804: NTP_transf_3
  • amino acids 3 to 57 (55 residues), 32.5 bits, E=9.8e-12

Best Hits

Swiss-Prot: 66% identical to RFBF_SALTI: Glucose-1-phosphate cytidylyltransferase (rfbF) from Salmonella typhi

KEGG orthology group: K00978, glucose-1-phosphate cytidylyltransferase [EC: 2.7.7.33] (inferred from 73% identity to cag:Cagg_2148)

MetaCyc: 67% identical to alpha-D-glucose-1-phosphate cytidylyltransferase monomer (Yersinia pseudotuberculosis)
Glucose-1-phosphate cytidylyltransferase. [EC: 2.7.7.33]

Predicted SEED Role

"Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33)" in subsystem dTDP-rhamnose synthesis (EC 2.7.7.33)

MetaCyc Pathways

• CDP-4-dehydro-3,6-dideoxy-D-glucose biosynthesis (1/3 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (2/5 steps found)
• superpathway of CDP-glucose-derived O-antigen building blocks biosynthesis (2/8 steps found)
• streptomycin biosynthesis (3/18 steps found)

KEGG Metabolic Maps

• Nucleotide sugars metabolism
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.33

Sequence Analysis Tools

See A0A1X9YNR4 at UniProt or InterPro

Protein Sequence (267 amino acids)

>CA264_02970 glucose-1-phosphate cytidylyltransferase (Pontibacter actiniarum KMM 6156, DSM 19842)
MKAVILAGGYGTRISEESGVRPKPMVEIGGKPILWHIMKIYSHYNINDFVICCGYKGHII
KEYFANYCLYNSDVTFDMRKNSMEVHKNHTESWKVTLVDTGEGTMTGGRLKRVQDYVGDD
TFCLTYGDGVSDVNIAEAIAYHKAQGTKATLTAVQQPGRFGAFTLSSEATKVPQFKEKPT
GGDMPWINGGFFVLEPSVFDYIEDDSTIWERGPLESLAEEGELSAYRHRGFWQPMDTLRD
KHVLEDLWQSGKAPWNVWHKMLSGAVN