Protein Info for CA264_02930 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: copper-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 744 transmembrane" amino acids 100 to 117 (18 residues), see Phobius details amino acids 123 to 140 (18 residues), see Phobius details amino acids 161 to 179 (19 residues), see Phobius details amino acids 191 to 210 (20 residues), see Phobius details amino acids 344 to 365 (22 residues), see Phobius details amino acids 376 to 401 (26 residues), see Phobius details amino acids 690 to 709 (20 residues), see Phobius details amino acids 716 to 737 (22 residues), see Phobius details PF00403: HMA" amino acids 13 to 74 (62 residues), 54.1 bits, see alignment 3.4e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 139 to 740 (602 residues), 617.6 bits, see alignment E=4.7e-189 TIGR01525: heavy metal translocating P-type ATPase" amino acids 158 to 739 (582 residues), 645.6 bits, see alignment E=1.7e-197 TIGR01494: HAD ATPase, P-type, family IC" amino acids 199 to 709 (511 residues), 313.1 bits, see alignment E=5.5e-97 PF00122: E1-E2_ATPase" amino acids 228 to 408 (181 residues), 205.1 bits, see alignment E=1.3e-64 PF00702: Hydrolase" amino acids 426 to 644 (219 residues), 123.7 bits, see alignment E=2.6e-39

Best Hits

Swiss-Prot: 47% identical to COPA_LEGPH: Copper-exporting P-type ATPase (copA) from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 59% identity to zpr:ZPR_3370)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YNL6 at UniProt or InterPro

Protein Sequence (744 amino acids)

>CA264_02930 copper-translocating P-type ATPase (Pontibacter actiniarum KMM 6156, DSM 19842)
MATIADKTLTKVTYPVEGMTCASCANSIESMLRSREGVEEANVNFAGKTVQVAYHEGQVT
PAQLRETVQEIGFDILIEQKTQEELEERQAKALAGLKRKTIVAGVLALPVFVLGMFFHDT
FSWGNWAMLVLTAPVLLWAGQRFFTGAWAQAKHFRANMDTLVALSTGIAFIFSVFNTVYP
EFFLSRGLMPHVYYEAVAVIIAFILLGKYLEEGAKDRSSSAIKKLMGLQPKTVRVLRNET
ELEIKIEEVQVGDRVVLLPGERIPVDGEVAAGTTYVDESMLSGEPLPVQKKPGDMLYAGT
INQKGSLQLIAQKTGGETMLAHIIKLVQEAQGSKAPVQKLVDRIAGIFVPVVLGIAILTF
AAWLVLGGEAYLTEALLSTISVLVIACPCALGLATPTAIMVGVGRGAENGILIKDAESLE
HAHKVNAVILDKTGTITLGKPSVTDVVWAQDTVMQQRLETLFFSMEAQSEHPIAQAIYTF
YKEQGQKALQPAYFNSLTGLGIEAEYDGKRYFAGNEKLLQQQGVELPAHLLQAARQLQED
AKTVIFFADAQQALAVFAVSDPIKPAAAEGIKAMHEAGLEIYMLTGDNRQTAEAVARQVG
VEHFQAELLPNDKAEFVKKLQAEGKVVAMVGDGINDAQALATADVSIAMGQGTDVAMDVA
GITLMRSDLTQVAKAVRLSRATVQTIRQNLFWAFFYNVICIPVAAGVLFPFTGFLLNPMI
AGAAMALSSVSVVTNSLRLRVKKV