Protein Info for CA264_02675 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 3 to 451 (449 residues), 484 bits, E=4.1e-149
• PF05893: LuxC
  • amino acids 24 to 286 (263 residues), 21 bits, E=1.4e-08

Best Hits

Swiss-Prot: 51% identical to GABD1_MYCTU: Succinate-semialdehyde dehydrogenase [NADP(+)] 1 (gabD1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 57% identity to mtt:Ftrac_0609)

MetaCyc: 52% identical to succinate-semialdehyde dehydrogenase monomer (Synechococcus sp. PCC 7002)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (7/9 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• 4-aminobutanoate degradation I (1/2 steps found)
• 4-aminobutanoate degradation II (1/2 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• GABA shunt I (2/4 steps found)
• GABA shunt II (2/4 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• 4-hydroxyphenylacetate degradation (3/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (6/13 steps found)
• nicotine degradation II (pyrrolidine pathway) (2/11 steps found)
• nicotine degradation I (pyridine pathway) (4/17 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24 or 1.2.1.79

Sequence Analysis Tools

See A0A1X9YNJ2 at UniProt or InterPro

Protein Sequence (454 amino acids)

>CA264_02675 succinate-semialdehyde dehydrogenase (Pontibacter actiniarum KMM 6156, DSM 19842)
MAIETVNPATGEVVKTFTPHTPEEVQQKIAAAEKAFQSWRGVSFEERARHMHRQADILEA
EAEKYGRIISLEMGKPVKDAMAEVKKCALACRYYAEHAADFMADEEIDSKASRSLISFEP
LGVVLAVMPWNFPFWQVYRFLAPALMAGNVGLLKHASNVPQCALAIEEIVQKAGFPDNVF
QTLLIGSKEVNAVIEHPHVKAVTLTGSETAGSKVAEKAGQEIKKTVLELGGSDAFIVLDD
ADLDKATEVASKSRMINVGQSCIAAKRFIVVESVADAFLQKFKTKMQSLKTGDPLKEEID
YGPLARADLAEELEKQVQESIRQGAEVVLDGGREGKGSAYFRPMILKNVKPGMPAYEEEM
FGPVAAVMVVKDEEEAIKVANDSRFGLGGAVWTQDKERGLRVARKVETGAMFVNALVASS
PEIPFGGIKKSGYGRELSYLGIREFVNQKSIWID