Protein Info for CA264_01425 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: RelA/SpoT family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 730 PF13328: HD_4" amino acids 37 to 186 (150 residues), 154.7 bits, see alignment E=5.1e-49 TIGR00691: RelA/SpoT family protein" amino acids 37 to 727 (691 residues), 645.6 bits, see alignment E=4.7e-198 PF01966: HD" amino acids 57 to 155 (99 residues), 32.7 bits, see alignment E=2.4e-11 PF04607: RelA_SpoT" amino acids 246 to 360 (115 residues), 126.4 bits, see alignment E=1.9e-40 PF02824: TGS" amino acids 403 to 462 (60 residues), 68.8 bits, see alignment 9.9e-23 PF19296: RelA_AH_RIS" amino acids 475 to 624 (150 residues), 27 bits, see alignment E=1.4e-09 PF13291: ACT_4" amino acids 653 to 728 (76 residues), 66.4 bits, see alignment E=9.1e-22

Best Hits

KEGG orthology group: K00951, GTP pyrophosphokinase [EC: 2.7.6.5] (inferred from 62% identity to phe:Phep_1204)

Predicted SEED Role

"GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase II / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2)" in subsystem Stringent Response, (p)ppGpp metabolism (EC 2.7.6.5, EC 3.1.7.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.6.5 or 3.1.7.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YMV1 at UniProt or InterPro

Protein Sequence (730 amino acids)

>CA264_01425 RelA/SpoT family protein (Pontibacter actiniarum KMM 6156, DSM 19842)
MIDLETERKEILRHYRRLLRYAKPFLKDNDAKIIKKAFNTSLEAHKDMRRKSGEPYILHP
LAVAQIAVEEIGLGTTSIVAALLHDVVEDTELETADIEREFGPSVARIIEGLTKISGVFD
YGTSQQAENFRKMLLTLSDDVRVILIKLADRLHNMRTLDSMPRHKQLKIASETMYLYAPL
AHRLGLYAIKSELEDLYLKYTDTDIYKDISNKIRQTRSARNKFIKDFIHPIEDELNKYGF
KFNIKGRPKSIYSILKKIKKQNITFDEIYDLFAIRIILDVPLENEKAACWQVYSIITDFY
QPNPDRLRDWVNTPKANGYESLHTTVMSKSGQWVEVQIRTKRMDEIAERGYAAHWKYKTE
GAASAESGLEQWINKVRDMLETNNSNALEFMDEFRKNLFVEEVFVFTPKGELIILPDKST
ALDFAFEIHSQIGLQCLGAKVNQKLVPLSYKLKNGDQVEILTSQKQKPNEEWLQYVVTSK
ARTRIKDALREERKNKAEQGKAMLEARLQLLEVPDTQQNLNKLQAFFNTPTLQDLYYRVA
TGHIDIKNIKQVIFTASADKGSSMLDLKSFDKEVQKIRGVNSDMLVIGETTSNWEYSMSK
CCNPIPGDDVFGFQTEDDGIEIHRTSCKRAMELMSNYGNRIIKAKWTEQKELAFLVGIRI
KGTDRVGLVNDLTKVISTSLKVNMRSITIDSNDGIFEGNIMVFVNDTGHLDKLIQRMGRV
HGILTVERFD