Protein Info for CA264_00100 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: acetate--CoA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16177: ACAS_N
  • amino acids 11 to 64 (54 residues), 72.3 bits, see alignment (E = 3.4e-24)
  • amino acids 665 to 720 (56 residues), 77.5 bits, see alignment (E = 8.1e-26)
• PF00501: AMP-binding
  • amino acids 72 to 452 (381 residues), 259.4 bits, E=7.6e-81
  • amino acids 722 to 1108 (387 residues), 304.9 bits, E=1.2e-94
• PF13193: AMP-binding_C
  • amino acids 517 to 596 (80 residues), 91.3 bits, 9.3e-30
  • amino acids 1170 to 1248 (79 residues), 78.4 bits, 9.8e-26
• TIGR02188: acetate--CoA ligase
  • amino acids 661 to 1282 (622 residues), 954.9 bits, E=1.8e-291

Predicted SEED Role

"Acetyl-coenzyme A synthetase (EC 6.2.1.1)" in subsystem Ketoisovalerate oxidoreductase or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 6.2.1.1)

MetaCyc Pathways

• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• acetate and ATP formation from acetyl-CoA III (1/1 steps found)
• acetate conversion to acetyl-CoA (1/1 steps found)
• L-isoleucine biosynthesis V (2/3 steps found)
• ethanol degradation III (2/3 steps found)
• chitin deacetylation (2/4 steps found)
• superpathway of acetate utilization and formation (1/3 steps found)
• reductive glycine pathway of autotrophic CO₂ fixation (4/9 steps found)
• adlupulone and adhumulone biosynthesis (1/6 steps found)
• colupulone and cohumulone biosynthesis (1/6 steps found)
• lupulone and humulone biosynthesis (1/6 steps found)
• cis-geranyl-CoA degradation (1/9 steps found)
• superpathway of bitter acids biosynthesis (3/18 steps found)

KEGG Metabolic Maps

• Glycolysis / Gluconeogenesis
• Propanoate metabolism
• Pyruvate metabolism
• Reductive carboxylate cycle (CO2 fixation)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.1

Sequence Analysis Tools

See A0A1X9YM59 at UniProt or InterPro

Protein Sequence (1285 amino acids)

>CA264_00100 acetate--CoA ligase (Pontibacter actiniarum KMM 6156, DSM 19842)
METLSPTPNNYAEAYAQSIADPEAFWGEQAEQLAWYEKPQQVLTTDENGFYRWYKGGKLN
TAYLALDYHVENGRGDQTALIYDSPVTGTIKKYTYAELRDFVARFAGALQQLGVGKGDTV
VIYMPVIPEAMVAMLACARLGAVHSVVFGGFAPHELCVRIDDAKPKVVISASCGIEFDKV
IPYKPLLDKALNDSTHKPEHTIIFQRPQVQAAMQQGRDLDYVEVLEQAAPADCVPVDATD
PLYILYTSGTTGKPKGIVRDNGGHAVALKYSMKAVYDVDPGDVFWAASDVGWAVGHSYLV
YGPLIHGCTSILFEGKPVRTPDAGTFWRIIQQHEVKVLFTAPTAFRAIKKEDPDGLLKKK
YDTPSLKYLFLAGERCDVSTYYWAKNLLQVPVIDHWWQTESGWPMVANMAGLELQPAKPG
SAGKPVCGYEVHILNEEGQQLIPNQEGVVAVKLPLPPGCLPTLWEDDERFRKSYLERFPG
YYMTGDGGYIDEEGYVYIMGRIDDVINVSGHRLSTGEMEEMVSSHPAVAECAVIGIADDL
RGQRPVGLVVLKDGQTIGEQELEQELVALLRDKIGAVAYFKTVVLVQRLPKTRSGKILRR
ILRHIADGTPYAVPSTIDDPAILTEIHDHLKARRIGNAFINLKTKSNQELHLAMTNYQVS
TYDEYQDAYKRSTEDPEGFWADVADTFTWRKKWDKVLEWNFEEPSVKWFQGGKMNITENC
LDRHLKTRGNKLALIWEPNDPKERFVRLTYRELHEKVCQFANVLKKNGAKKGDRICIYMP
MVPELAIAVLACARIGAIHSVVFAGFSASAMADRINDAQCSMVLTSDGLNRGAKQIPVKR
VVDEALEDCTSVKKVIVVERLGWAVNMVEGRDVWYHDEVQTVGKDCPAEEMDAEDMLFIL
YTSGSTGKPKGVVHTCGGYMVYAQYSFCNVFQYQESDVYWCTADIGWITGHTYLVYGPLL
AGATTLMFEGVPTYPDMGRFWQVVDKFGVTIFYTAPTAIRALMGGDLDNVLSYSLDSLRV
LGSVGEPINEEAWHWYHIHVGKEDCPVVDTWWQTETGGIMISTLADVTPMKPSHAGLPLP
GIQPILVDSDGNEITENGVEGYLCVKFPWPSMIRTTYGDHERARLSYFSTYKGLYFTGDG
AKRDENGLYRIIGRVDDVINVSGHRFGTAEIEEAINHNEHVIESAVVGYPHDVKGQGIYA
FVILKDKPERDDWLRAEIIETVVEKIGKIAKPDKIQIVSGLPKTRSGKIMRRILRKVAEG
DTSNLGDTSTLLDPEVVEEIKNGAL