Protein Info for CA264_00045 in Pontibacter actiniarum KMM 6156, DSM 19842

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 829 PF02190: LON_substr_bdg" amino acids 45 to 238 (194 residues), 176.4 bits, see alignment E=1.5e-55 TIGR00763: endopeptidase La" amino acids 47 to 807 (761 residues), 950.8 bits, see alignment E=3.6e-290 PF00004: AAA" amino acids 388 to 527 (140 residues), 96 bits, see alignment E=5.1e-31 PF07728: AAA_5" amino acids 388 to 522 (135 residues), 43.8 bits, see alignment E=5.4e-15 PF05362: Lon_C" amino acids 606 to 808 (203 residues), 279.8 bits, see alignment E=2.5e-87

Best Hits

Swiss-Prot: 66% identical to LON_CYTH3: Lon protease (lon) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 72% identity to mtt:Ftrac_0807)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9YM47 at UniProt or InterPro

Protein Sequence (829 amino acids)

>CA264_00045 endopeptidase La (Pontibacter actiniarum KMM 6156, DSM 19842)
MNHTLEHFLQNLLLSSISDDESIELIPVITADAEDDIKQEDLPEELPILAVRNTVLFPGV
VLPITVSRKKSVKLVRKAHSGGQVIGVVAQKNTGSDDPTAEDLYDIGTVAKILKMLVLPD
GNTTIIIQGQSRFKIEEVTQEEPYLAARVSLCQETPMDKSKKEVKALVQSLKDAAAKMLK
LNPEIPQEAQVALDNIDSPSFLTHFLSSNLNVEMAQKQELLEVNDGKERGTLLLELMLRE
IQLLELKQEIHSKVHTDIDQQQRDYFLRQQIKVLQDELGQEGPDQEIERFRERAKKKKWP
EAVAQHFKKEIDKLARLNPQAAEYPVAVNYLEFLLDLPWDEHTKDNFNLKRTKKILDADH
YGLEKVKERILEYLAVLKLKNDMKAPILCLYGPPGVGKTSLGRSIAKALGRNYVRMSLGG
VRDEAEIRGHRRTYVGAMPGKIISQIKKTGSSNPVIILDEIDKLASDFRGDPSSALLEVL
DPEQNHTFMDNYLDVEYDLSKVLFIATANSLETIQPALRDRMEIIELTGYTLEEKTEIAK
RHLVPKQVEEHGLEPEDVKVPKPTIHKVIEDYTRESGVRSLERKIGQLMRNTAKQKAMDE
EFVKTIKPDDVVKILGSEIFDKEIYQDIDTAGVVTGLAWTSVGGDILFIESILSRGKGKL
TLSGQLGDVMKESAMTAISYLKAHAELLDIDYRLFDQYDLHIHFPEGAVPKDGPSAGIAI
FTSIASVFTQRKVRPRLAMTGEITLRGKVLPVGGIKEKILAAKRAGVTDIILCQKNKKDI
NEIPEQYIKGLTIHYVDRVDDVVKIALLKEKVKYPLKLEVKEEKADAEK