Protein Info for BNILDI_14505 in Escherichia coli ECRC62

Name: alkA
Annotation: DNA-3-methyladenine glycosylase 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF06029: AlkA_N
  • amino acids 3 to 112 (110 residues), 106.9 bits, E=7.5e-35
• PF00730: HhH-GPD
  • amino acids 118 to 239 (122 residues), 37.8 bits, E=2.1e-13

Best Hits

Swiss-Prot: 97% identical to 3MG2_ECOLI: DNA-3-methyladenine glycosylase 2 (alkA) from Escherichia coli (strain K12)

KEGG orthology group: K01247, DNA-3-methyladenine glycosylase II [EC: 3.2.2.21] (inferred from 99% identity to ecy:ECSE_2342)

MetaCyc: 97% identical to DNA-3-methyladenine glycosylase 2 (Escherichia coli K-12 substr. MG1655)
DNA-3-methyladenine glycosylase II. [EC: 3.2.2.21]

Predicted SEED Role

"DNA-3-methyladenine glycosylase II (EC 3.2.2.21)" in subsystem DNA Repair Base Excision (EC 3.2.2.21)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.2.21

Protein Sequence (285 amino acids)

>BNILDI_14505 DNA-3-methyladenine glycosylase 2 (Escherichia coli ECRC62)
MYTLNWQPPYDWSWMLGFLAARAVSGVETVAEDYYARSLAVGEYRGVVTAIPDIARHTLH
INLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGKLGAARPGLRLPGCIDAFEQGVRA
ILGQLVSVAMAAKLTAKVVQLYGERLDDFPEYICFPTPQRLAAADPQALKALGMPLKRAE
ALIHLANAALEGSLPMTIPGDVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYL
IKQRFPGMTPAQIRRYAERWKPWRSYALLHIWYTEGWQPDGTDEL