Protein Info for BNILDI_14030 in Escherichia coli ECRC62

Name: mglA
Annotation: galactose/methyl galactoside ABC transporter ATP-binding protein MglA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 PF00005: ABC_tran" amino acids 29 to 178 (150 residues), 105.3 bits, see alignment E=4.3e-34 amino acids 280 to 434 (155 residues), 70.4 bits, see alignment E=2.6e-23

Best Hits

Swiss-Prot: 100% identical to MGLA_SHIFL: Galactose/methyl galactoside import ATP-binding protein MglA (mglA) from Shigella flexneri

KEGG orthology group: K10542, methyl-galactoside transport system ATP-binding protein [EC: 3.6.3.17] (inferred from 100% identity to eco:b2149)

MetaCyc: 100% identical to D-galactose/methyl-galactoside ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
ABC-18-RXN; TRANS-RXN0-541

Predicted SEED Role

"Galactose/methyl galactoside ABC transport system, ATP-binding protein MglA (EC 3.6.3.17)" in subsystem Lactose and Galactose Uptake and Utilization (EC 3.6.3.17)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.17

Use Curated BLAST to search for 3.6.3.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (506 amino acids)

>BNILDI_14030 galactose/methyl galactoside ABC transporter ATP-binding protein MglA (Escherichia coli ECRC62)
MVSSTTPSSGEYLLEMSGINKSFPGVKALDNVNLKVRPHSIHALMGENGAGKSTLLKCLF
GIYQKDSGTILFQGKEIDFHSAKEALENGISMVHQELNLVLQRSVMDNMWLGRYPTKGMF
VDQDKMYRETKAIFDELDIDIDPRARVGTLSVSQMQMIEIAKAFSYNAKIVIMDEPTSSL
TEKEVNHLFTIIRKLKERGCGIVYISHKMEEIFQLCDEVTVLRDGQWIATEPLAGLTMDK
IIAMMVGRSLNQRFPDKENKPGEVILEVRNLTSLRQPSIRDVSFDLHKGEILGIAGLVGA
KRTDIVETLFGIREKSAGTITLHGKQINNHNANEAINHGFALVTEERRSTGIYAYLDISF
NSLISNIRNYKNKVGLLDNSRMKSDTQWVIDSMRVKTPGHRTQIGSLSGGNQQKVIIGRW
LLTQPEILMLDEPTRGIDVGAKFEIYQLIAELAKKGKGIIIISSEMPELLGITDRILVMS
NGLVSGIVDTKTTTQNEILRLASLHL