Protein Info for BNILDI_01450 in Escherichia coli ECRC62

Name: kbaY
Annotation: tagatose-bisphosphate aldolase subunit KbaY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00167: ketose-bisphosphate aldolase
  • amino acids 1 to 284 (284 residues), 368.8 bits, E=2e-114
• TIGR01858: class II aldolase, tagatose bisphosphate family
  • amino acids 3 to 284 (282 residues), 541.3 bits, E=4.2e-167
• PF01116: F_bP_aldolase
  • amino acids 5 to 283 (279 residues), 335.2 bits, E=1.7e-104

Best Hits

Swiss-Prot: 100% identical to KBAY_ECO57: D-tagatose-1,6-bisphosphate aldolase subunit KbaY (kbaY) from Escherichia coli O157:H7

KEGG orthology group: K08302, tagatose 1,6-diphosphate aldolase [EC: 4.1.2.40] (inferred from 100% identity to eco:b3137)

MetaCyc: 100% identical to D-tagatose-1,6-bisphosphate aldolase subunit KbaY (Escherichia coli O157:H7)
Tagatose-bisphosphate aldolase. [EC: 4.1.2.40]

Predicted SEED Role

"Tagatose 1,6-bisphosphate aldolase (EC 4.1.2.40)" in subsystem D-Tagatose and Galactitol Utilization or Lactose and Galactose Uptake and Utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 4.1.2.40)

MetaCyc Pathways

• superpathway of hexitol degradation (bacteria) (18/18 steps found)
• galactitol degradation (5/5 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (4/4 steps found)
• N-acetyl-D-galactosamine degradation (4/5 steps found)
• D-tagatose degradation (1/3 steps found)
• lactose degradation I (2/5 steps found)

KEGG Metabolic Maps

• Galactose metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.2.40

Use Curated BLAST to search for 4.1.2.40

Protein Sequence (286 amino acids)

>BNILDI_01450 tagatose-bisphosphate aldolase subunit KbaY (Escherichia coli ECRC62)
MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALE
EIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSV
VDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAH
GLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA
GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA