Protein Info for BACOVA_05597 in Bacteroides ovatus ATCC 8483

Annotation: formate C-acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01255: formate acetyltransferase
  • amino acids 7 to 742 (736 residues), 1102.1 bits, E=0
• PF02901: PFL-like
  • amino acids 15 to 601 (587 residues), 642.3 bits, E=1.1e-196
• PF01228: Gly_radical
  • amino acids 617 to 723 (107 residues), 135.3 bits, E=1.1e-43

Best Hits

Swiss-Prot: 61% identical to PFL_CLOPA: Formate acetyltransferase (pfl) from Clostridium pasteurianum

KEGG orthology group: K00656, formate C-acetyltransferase [EC: 2.3.1.54] (inferred from 98% identity to bth:BT_4738)

MetaCyc: 61% identical to pyruvate formate-lyase subunit (Clostridium pasteurianum)
Formate C-acetyltransferase. [EC: 2.3.1.54]

Predicted SEED Role

"Pyruvate formate-lyase (EC 2.3.1.54)" in subsystem Butanol Biosynthesis or Fermentations: Mixed acid (EC 2.3.1.54)

MetaCyc Pathways

• superpathway of N-acetylneuraminate degradation (17/22 steps found)
• pyruvate fermentation to acetate IV (3/3 steps found)
• L-threonine degradation I (5/6 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (10/13 steps found)
• reductive monocarboxylic acid cycle (2/2 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (7/9 steps found)
• mixed acid fermentation (12/16 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (14/19 steps found)
• superpathway of L-threonine metabolism (13/18 steps found)
• pyruvate fermentation to ethanol I (2/3 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Propanoate metabolism
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.54

Protein Sequence (742 amino acids)

>BACOVA_05597 formate C-acetyltransferase (Bacteroides ovatus ATCC 8483)
MELNKIFKDGLWSTEINVRDFVSHNITPYYGDASFLEGPTERTKAVWNRCLEALAEERAN
NGVRSLDNVTVSTITSHKAGYIDKENELIVGLQTDELLKRAIKPFGGINVVSKACHENGV
EVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPDNYARGRIIGDYRRMALY
GIDRLIEAKKEDLRNLTGPMTDARIRLREEVAEQIKALKDMKVMGEYYGLDLSRPAYTAQ
EAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYMEYELSKGTITESFAQELIDQFVIKL
RMVRHLRMQSYNDIFAGDPTWVTESLGGRLNDGRTKVTKTSFRFLQTLYNLGPSPEPNLT
VLWSPELPEGFKEFCAKVSIDTSSIQYENDDLMREVRQSDDYGIACCVSYQEIGKQIQFF
GARCNLAKALLLAINGGRCENTGTVMVKNIPVLTSDTLNFEEVMSNYKKVLTEIARVYNE
AMNIIHYMHDKYYYEKAQMALVDTNPRINLAYGVAGLSIALDSLSAIKYAKVTARRNDIG
LTEGFDIQGEFPCFGNDNDKVDHLGVDLVYFFSEELKKLPVYKNARPTLSLLTITSNVMY
GKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIASLSSVAKLRYRDSQDGISNTFSIVPK
SLGATEEDRVENLVTMMDGYFTKGAHHLNVNVLNREMLYDAMEHPEKYPQLTIRVSGYAV
NFVKLSREHQLEVISRSFHERM