Protein Info for BACOVA_04431 in Bacteroides ovatus ATCC 8483

Annotation: carboxyl transferase domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 64% identical to PCCB_RHOS4: Propionyl-CoA carboxylase beta chain (pccB) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

KEGG orthology group: None (inferred from 98% identity to bth:BT_1686)

MetaCyc: 64% identical to propionyl-CoA carboxylase beta subunit (Cereibacter sphaeroides)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]

Predicted SEED Role

"Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)" in subsystem Na+ translocating decarboxylases and related biotin-dependent enzymes or Propionyl-CoA to Succinyl-CoA Module (EC 4.1.1.41)

MetaCyc Pathways

propanoyl CoA degradation I (3/3 steps found)
2-oxobutanoate degradation I (3/4 steps found)
anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
methylaspartate cycle (11/19 steps found)
3-hydroxypropanoate cycle (5/13 steps found)
superpathway of L-methionine salvage and degradation (7/16 steps found)
3-hydroxypropanoate/4-hydroxybutanate cycle (5/18 steps found)
superpathway of the 3-hydroxypropanoate cycle (5/18 steps found)
mycolate biosynthesis (23/205 steps found)
superpathway of mycolate biosynthesis (24/239 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.41, 6.4.1.3

Use Curated BLAST to search for 4.1.1.41 or 6.4.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (517 amino acids)

>BACOVA_04431 carboxyl transferase domain protein (Bacteroides ovatus ATCC 8483)
MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAMLLDEGSFEEMDMFVEH
RCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLSETMSLKICKIMDQAMK
MGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQISGIFGPCAGGAVYSPAL
TDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHFTAQTEEEGFEL
IRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPTKPYDMYEVIGAIVDNGEFL
EIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNASRKGARFVRFCDAFNIPIVS
LVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTITLRKSYGGSHIVMSCKQLRGD
MNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLAEKEAEYTKLFANPYNAAKYGYI
DDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL