Protein Info for BACOVA_03666 in Bacteroides ovatus ATCC 8483

Annotation: methylenetetrahydrofolate reductase (NAD(P)H)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02219: MTHFR
  • amino acids 8 to 314 (307 residues), 201.5 bits, E=9.3e-64
• TIGR00676: methylenetetrahydrofolate reductase [NAD(P)H]
  • amino acids 15 to 316 (302 residues), 338.8 bits, E=1.2e-105

Best Hits

KEGG orthology group: K00297, methylenetetrahydrofolate reductase (NADPH) [EC: 1.5.1.20] (inferred from 94% identity to bth:BT_3821)

Predicted SEED Role

"5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)" in subsystem Methionine Biosynthesis or One-carbon metabolism by tetrahydropterines or Serine-glyoxylate cycle (EC 1.5.1.20)

MetaCyc Pathways

• folate transformations I (9/13 steps found)

KEGG Metabolic Maps

• Methane metabolism
• One carbon pool by folate

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.1.20

Protein Sequence (317 amino acids)

>BACOVA_03666 methylenetetrahydrofolate reductase (NAD(P)H) (Bacteroides ovatus ATCC 8483)
MKVIDLINNSKGTAFSFEILPPLKGTGIEKLYQTIDTLREFDPKYINITTHRSEYVYKDL
GNGLFQRNRLRRRPGTVAVAAAIQNKYNITVVPHILCSGFTREETEYVLLDLQFLNITDL
LVLRGDKAKHESVFTPEGDGYHHAIELQEQINNFNKGIFVDGSEMKVTASPFSYGVACYP
EKHEESPNIETDLYWLKKKVETGAEYAVTQLFYDNKKYFDFVEQAKAAGINIPIIPGIKP
FKKISQLSMIPKTFKVDLPEDLVKEALKCKNDAEAEQVGVEWCVAQCKELMEHGVPSIHF
YSIGAVDSIKEIAKIIY