Protein Info for BACOVA_02641 in Bacteroides ovatus ATCC 8483

Annotation: ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 625 PF02518: HATPase_c" amino acids 49 to 178 (130 residues), 43 bits, see alignment E=1.4e-14 PF13589: HATPase_c_3" amino acids 56 to 165 (110 residues), 31.6 bits, see alignment E=3.9e-11 PF00204: DNA_gyraseB" amino acids 244 to 376 (133 residues), 99.7 bits, see alignment E=3.4e-32 PF01751: Toprim" amino acids 419 to 525 (107 residues), 55.6 bits, see alignment E=1.3e-18 PF00986: DNA_gyraseB_C" amino acids 556 to 613 (58 residues), 31.3 bits, see alignment 4.8e-11

Best Hits

Swiss-Prot: 52% identical to PARE_BORBU: DNA topoisomerase 4 subunit B (parE) from Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)

KEGG orthology group: K02622, topoisomerase IV subunit B [EC: 5.99.1.-] (inferred from 97% identity to bth:BT_3033)

Predicted SEED Role

"Topoisomerase IV subunit B (EC 5.99.1.-)" in subsystem DNA topoisomerases, Type II, ATP-dependent or Resistance to fluoroquinolones (EC 5.99.1.-)

Isozymes

Compare fitness of predicted isozymes for: 5.99.1.-

Use Curated BLAST to search for 5.99.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (625 amino acids)

>BACOVA_02641 ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein (Bacteroides ovatus ATCC 8483)
MEENELIPVDNNNAVEYTDDNIRHLSDMEHVRTRPGMYIGRLGDGAHAEDGIYVLLKEVI
DNSIDEFKMQAGKKIEITVEENLRVSVRDYGRGIPQGKLIEAVSMLNTGGKYDSKAFKKS
VGLNGVGVKAVNALSSRFEVRSYRDGKVRIATFSKGNLLTDETKNTEEENGTYIFFEPDN
TLFLNYCFKPEFIETMLRNYTYLNTGLAIIYNGHRILSRNGLVDLLNDNMTATGLYPIIH
LKGEDIEIAFTHTGQYGEEYYSFVNGQHTTQGGTHQSAFKEHIARTIKEFFNKNMDYTDI
RNGLVAAIAVNVEEPIFESQTKTKLGSTNMVPGGVTVNKYVGDFIKQEVDNFLHKNADIA
EVIQQKIQESEKERKAIAGVTKLARERAKKANLHNRKLRDCRIHLNDPKGKGLEEDSCIF
ITEGDSASGSITKSRDVNTQAVFSLRGKPLNSFGLTKKVVYENEEFNLLQAALNIEDGIE
GLRYNKVIVATDADVDGMHIRLLLITFFLQFFPDLIKKGHVYILQTPLFRVRNKKKTNYC
YSEEERINAINELGPNPEITRFKGLGEISPDEFKHFIGKDMRLEQVTLRKTDAVKELLEF
YMGKNTMERQNFIIDNLVIEEDLAS