Protein Info for BACOVA_02088 in Bacteroides ovatus ATCC 8483
Annotation: N-acylglucosamine 2-epimerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 68% identical to CEEP_BACFN: Cellobiose 2-epimerase (bfce) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
KEGG orthology group: None (inferred from 66% identity to bhl:Bache_0225)MetaCyc: 68% identical to cellobiose 2-epimerase / mannobiose 2-epimerase (Bacteroides fragilis NCTC 9343)
Cellobiose epimerase. [EC: 5.1.3.11]; 5.1.3.11 [EC: 5.1.3.11]
Predicted SEED Role
"N-acylglucosamine 2-epimerase (EC 5.1.3.8)" in subsystem Sialic Acid Metabolism (EC 5.1.3.8)
MetaCyc Pathways
- β-(1,4)-mannan degradation (6/7 steps found)
- N-acetylneuraminate and N-acetylmannosamine degradation II (2/3 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 5.1.3.8
Use Curated BLAST to search for 5.1.3.11 or 5.1.3.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (396 amino acids)
>BACOVA_02088 N-acylglucosamine 2-epimerase (Bacteroides ovatus ATCC 8483) METTIERLKEEVQQVLTTNILPYWIEKMQDRGNGGFYGRITGQECLVAEAEKGAVMNARI LWTFSAAYRLLHKTEYLEIATRAKREIIDRFYDTQFGGVYWSIDAHGQPLDTKKQVYAIG FAIYGLSEYHRATADDEALEYAVRLFHDIELHCFDKGKNGYYEAFSREWGEIADMRLSDK DANERKTMNTHLHILEPYTNLFRIWKDEMLKSRLHNLIRLFIDEIMDMDTRHLQLFFDDN WRSNYHIISYGHDIEASWLIHEAALVLADRQLLTEIEMYIVEMAEAAAEGFLSDGGMIYE LRTDSSSIDADRHWWVQAETVVGFMNLYQHFGDKLSLSRAVRCWEFIKKYLIDYANGEWY WSLSADGTVNREDDKAGFWKCPYHNGRMCMEIMERF