Protein Info for BACOVA_01991 in Bacteroides ovatus ATCC 8483

Annotation: efflux transporter, RND family, MFP subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 391 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 33 to 364 (332 residues), 269.8 bits, see alignment E=1.3e-84 PF16576: HlyD_D23" amino acids 56 to 280 (225 residues), 67.2 bits, see alignment E=3.2e-22 PF13533: Biotin_lipoyl_2" amino acids 57 to 104 (48 residues), 44.7 bits, see alignment 2.3e-15 PF02321: OEP" amino acids 92 to 163 (72 residues), 22.3 bits, see alignment E=2.6e-08 PF13437: HlyD_3" amino acids 167 to 276 (110 residues), 28 bits, see alignment E=7.5e-10

Best Hits

KEGG orthology group: K03585, membrane fusion protein (inferred from 91% identity to bth:BT_3339)

Predicted SEED Role

"Membrane fusion protein of RND family multidrug efflux pump" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (391 amino acids)

>BACOVA_01991 efflux transporter, RND family, MFP subunit (Bacteroides ovatus ATCC 8483)
MKSRIVLFAFCVALLSSCGNKGNDTGKVPEYAVQELQKTTANLTTAYPATIKGKQDVEIR
PQVSGFITKLCVDEGAAVRKGQVLFIVDPTQYEAAVRTAKAAVATAEAAVSTQQMTYDNK
KELNKKQIISDYDLAMAENSLAQTKAQLAQAKAQLTTAQQNLSFTQVKSPSDGVINNIPY
RVGALVSPSIATPMTTVSEIDEVYVYFSMTEKELLAMTKSGSTIKEEISKIPTIKLQLID
GSTYDIEGKVDAITGVIDQSTGSVSIRAIFPNKEHVLRSGGTANVLIPYAMENVITIPQS
ATVEIQDKKFVYVLQPDNTVKYTEIKIFNLDNGKDYLVTSGLNSGDKIVIEGVQNLKDGQ
KVQPITPAQKEANYQQHLKDQHDGNLATAFN