Protein Info for BACOVA_01463 in Bacteroides ovatus ATCC 8483
Annotation: carboxyl transferase domain protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to PCCB_HALMT: Propionyl-CoA carboxylase, carboxyltransferase subunit (pccB) from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)
KEGG orthology group: None (inferred from 96% identity to bth:BT_1917)MetaCyc: 60% identical to (S)-methylmalonyl-CoA decarboxylase alpha subunit (Veillonella parvula)
RXN-19738 [EC: 7.2.4.3]
Predicted SEED Role
"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2); Propionyl-CoA carboxylase beta chain (EC 6.4.1.3)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2, EC 6.4.1.3)
MetaCyc Pathways
- propanoyl CoA degradation I (3/3 steps found)
- (S)-lactate fermentation to propanoate, acetate and hydrogen (10/13 steps found)
- 2-oxobutanoate degradation I (3/4 steps found)
- fatty acid biosynthesis initiation (type I) (1/3 steps found)
- anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
- superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
- methylaspartate cycle (11/19 steps found)
- jadomycin biosynthesis (3/9 steps found)
- 3-hydroxypropanoate cycle (5/13 steps found)
- superpathway of L-methionine salvage and degradation (7/16 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (5/18 steps found)
- superpathway of the 3-hydroxypropanoate cycle (5/18 steps found)
- mycolate biosynthesis (23/205 steps found)
- superpathway of mycolate biosynthesis (24/239 steps found)
KEGG Metabolic Maps
- Fatty acid biosynthesis
- Propanoate metabolism
- Pyruvate metabolism
- Tetracycline biosynthesis
- Valine, leucine and isoleucine degradation
Isozymes
Compare fitness of predicted isozymes for: 6.4.1.2, 6.4.1.3
Use Curated BLAST to search for 6.4.1.2 or 6.4.1.3 or 7.2.4.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (511 amino acids)
>BACOVA_01463 carboxyl transferase domain protein (Bacteroides ovatus ATCC 8483) MEEINKAYATFEERDRIASLGGGVDKIEKQHESGKMTARERIEMLLDKGTFVELDKLMVH RCTNYGMDKNKIPGDGIVSGYGKVDGRQVFVYAYDFTVYGGSLSASNAKKIVKVQQLALK NGAPIIALNDSGGARIQEGIESLSGYADIFYQNTMASGVIPQISAILGPCAGGACYSPAL TDFIFMVKEKSHMFVTGPDVVKTVIHEEVSKEELGGAMTHSSKSGVTHFMCNTEEELLMS IRELLSFLPQNNMDEAKKKPCTDETNREDTSLDTIVPVDPNVPYDMKDIIERVIDNGYFF EVMPNFAKNIIIGFARMAGRSVGIVANQPAYLAGVLDIDASDKASRFIRFCDCFNIPLIT FEDVPGFLPGYTQENNGIIRHGAKIVYAFAEATVPKLTVITRKAYGGAYIVMNSKQTGAD VNFAYPSAEIAVMGADGAINILFRKADEATKAKELEAYKEKFATPYQAAELGYIDEIIYP RQTRKRLIQALEMTENKMQTNPPKKHGNMPL