Protein Info for BACOVA_01333 in Bacteroides ovatus ATCC 8483
Annotation: mannonate dehydratase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01686, mannonate dehydratase [EC: 4.2.1.8] (inferred from 90% identity to bth:BT_0129)Predicted SEED Role
"Mannonate dehydratase (EC 4.2.1.8)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 4.2.1.8)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (10/10 steps found)
- superpathway of β-D-glucuronosides degradation (7/7 steps found)
- D-fructuronate degradation (4/4 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (16/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.8
Use Curated BLAST to search for 4.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (395 amino acids)
>BACOVA_01333 mannonate dehydratase (Bacteroides ovatus ATCC 8483) MMEKTWRWFGKKDKITLPMLRQIGVEGIVTALHDVPNGEIWTVEAINDLKSYIESYGLRW SVVESLPVCEAIKYAGAEREQLIENYKVSLANLGKCGIKTVCYNFMPVIDWIRTDLQHPW PDGTSSLYYDRIRFAYFDIRILEREGAEKDYTEEELQKVAELDKVITEAEKDALIDTIIV KTQGFVNGNIKEGDKNPVSIFKRLLALYKDINRDALRENMRYFLSAIMPVCEEYGVNMCV HPDDPPFQVLGLPRIVTNENDIEWFLNAVDNPHNGLTFCAGSLSADEHNDTRELAKKFAK RTHFVHLRSTAAMQGGNFIESSHLTGRGHLIDLIRIFENENPGLPMRVDHGRMMLGDEDK GYNPGYSFHGRMLALAQVEGMMAVVDDEKRRQIIL