Protein Info for BACOVA_00399 in Bacteroides ovatus ATCC 8483

Annotation: amidohydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00857: dihydroorotase, multifunctional complex type
  • amino acids 18 to 430 (413 residues), 299 bits, E=2.9e-93
• PF01979: Amidohydro_1
  • amino acids 53 to 426 (374 residues), 75.8 bits, E=3.9e-25

Best Hits

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 89% identity to bth:BT_0250)

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (16/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (6/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• UMP biosynthesis I (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.3

Protein Sequence (445 amino acids)

>BACOVA_00399 amidohydrolase family protein (Bacteroides ovatus ATCC 8483)
MKRTLIQNAVVVNEGRKVLGSVVIENEKIAEILVGEENATAPCDEIIDATGCYLLPGAID
EHVHFRDPGLTHKADITTESRAAAAGGVTSIMDMPNTNPQTTTLEALEEKFVLLGEKSAV
NYSCYFGATNNNYTQFAQLDKHRVCGVKLFMGSSTGNMLVDRMASLRNIFGGTDLLIAAH
CEDQGIIKENTDKYKKEYGDDVPLALHPLLRSEEACYRSSELAVQLARETNARLHIMHIS
TAKELSLFSNVPLVQKKITAEACVSHLLFTEEDYQTLGARIKCNPAIKTAQDRKALREAV
NSGLIDAIATDHAPHLLSEKEGGALKAMSGMPMIQFSLVSMLELTEKGVFTIEKVVEKMA
HAPAQMYEIQNRGFIRKGYQADLVLVRPGSEWTVTTDCILSKCKWSPLEGHTFDWKVEKT
FVNGHLLYNNGEIDETYRGQELRFR