Protein Info for BACOVA_00344 in Bacteroides ovatus ATCC 8483

Annotation: DNA mismatch repair domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 633 TIGR00585: DNA mismatch repair protein MutL" amino acids 5 to 306 (302 residues), 297.8 bits, see alignment E=6.3e-93 PF02518: HATPase_c" amino acids 23 to 79 (57 residues), 33.9 bits, see alignment 7.4e-12 PF13589: HATPase_c_3" amino acids 26 to 127 (102 residues), 46.1 bits, see alignment E=1e-15 PF01119: DNA_mis_repair" amino acids 209 to 326 (118 residues), 120 bits, see alignment E=8.8e-39 PF08676: MutL_C" amino acids 453 to 589 (137 residues), 98.8 bits, see alignment E=4.7e-32

Best Hits

Swiss-Prot: 92% identical to MUTL_BACTN: DNA mismatch repair protein MutL (mutL) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 92% identity to bth:BT_3851)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (633 amino acids)

>BACOVA_00344 DNA mismatch repair domain protein (Bacteroides ovatus ATCC 8483)
MSDIIHLLPDSVANQIAAGEVIQRPASVIKELVENAIDADAQNIHVLVTDAGKTCIQVID
DGKGMSETDARLSFERHATSKIREAADLFALRTMGFRGEALASIAAVAQVELKTRPESEE
LGTKLVIAGSQVESQEAISCSKGSNFSVKNLFFNVPARRKFLKANSTELSNILAEFERIA
LVHPEVAFSLYSNDSELFNLPVSQLRQRILAIFGKKLNQQLLNIDVNTTMVKISGYVAKP
ETARKKGAHQYFFVNGRYMRHPYFHKAVMEAYEQLIPAGEQISYFIYFDVDPANIDVNIH
PTKTEIKFENEQAIWQILSASVKESLGKFSAIPSIDFDTEDMPDIPAFEEKISSEPPKVH
YNTDYNPFKVSAGGGGGGSYSRSKVEWEDLYGGLTKASKMNNPQPEPEMDWEDSSIGGEP
AFVEEKIETVTSAASSTLYANEPVMEKGNQHLQFKGRFILTSVKSGLMLIDQHRAHIRVL
FDRYMVQIQQKQGVSQGVLFPEILQLPASEAAVLQSIMDDLSAVGFDLSNLGGGSYAING
IPSGIEGLNPVELVRNMLHTAMEKGNDVKEEIQNILALTLARAAAIVYGQVLSNEEMVSL
VDNLFACPSPNYTPDGKTVLTTIKEEDIERLFK