Protein Info for B158DRAFT_2497 in Kangiella aquimarina DSM 16071

Annotation: Adenylosuccinate lyase (EC 4.3.2.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00928: adenylosuccinate lyase
  • amino acids 12 to 453 (442 residues), 463.2 bits, E=4.2e-143
• PF00206: Lyase_1
  • amino acids 14 to 311 (298 residues), 222.7 bits, E=7.9e-70
• PF08328: ASL_C
  • amino acids 330 to 444 (115 residues), 172.8 bits, E=2.4e-55

Best Hits

Swiss-Prot: 72% identical to PUR8_HAEIN: Adenylosuccinate lyase (purB) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K01756, adenylosuccinate lyase [EC: 4.3.2.2] (inferred from 95% identity to kko:Kkor_1046)

MetaCyc: 71% identical to adenylosuccinate lyase (Escherichia coli K-12 substr. MG1655)
Adenylosuccinate lyase. [EC: 4.3.2.2]; 4.3.2.2 [EC: 4.3.2.2]

Predicted SEED Role

"Adenylosuccinate lyase (EC 4.3.2.2)" in subsystem De Novo Purine Biosynthesis or Purine conversions (EC 4.3.2.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• superpathway of purine nucleotide salvage (11/14 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)
• dZTP biosynthesis (3/5 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Biosynthesis of alkaloids derived from histidine and purine
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.2.2

Protein Sequence (454 amino acids)

>B158DRAFT_2497 Adenylosuccinate lyase (EC 4.3.2.2) (Kangiella aquimarina DSM 16071)
MQLSALTAISPVDGRYGSKVTDLRSIFSEFGLLKYRVTVEVRWLQALAQADAIKEVPAFS
DEANQLLNSIVDYFAESDAEKIKEIERTTNHDVKAVEYFLKEKIRHSNELDNVSEFIHFA
CTSEDINNLSYALMLKEGTEALAKYQQEICQSIRSLADQFVEIPMMSRTHGQPASPSTMG
KEMANVVYRLERQLKQIQNQEILGKINGAVGNYNAHLSAYPDFDWQSFAEKFVTSLGLTW
NPYTTQIEPHDYMAELFDAIARFNTIVIDFDRDVWGYIALGHFKQKTIAGEIGSSTMPHK
VNPIDFENSEGNLGIANALFDHLAMKLPISRWQRDLSDSTVQRVLGVGYAHSVIAYQATL
KGISKLEVNEKSLLDELNANWELLAEPIQTVMRRYAIPNPYEKLKELTRGKRVTREDMQA
FIDSLELPEDEKQRLKQLTPATYIGNAVSQTKKI