Protein Info for B158DRAFT_2453 in Kangiella aquimarina DSM 16071

Annotation: quinolinate synthetase (EC 2.5.1.72)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00550: quinolinate synthetase complex, A subunit
  • amino acids 31 to 341 (311 residues), 374.3 bits, E=2.3e-116
• PF02445: NadA
  • amino acids 35 to 339 (305 residues), 356.1 bits, E=7e-111

Best Hits

Swiss-Prot: 70% identical to NADA_YERPA: Quinolinate synthase A (nadA) from Yersinia pestis bv. Antiqua (strain Antiqua)

KEGG orthology group: K03517, quinolinate synthase [EC: 2.5.1.72] (inferred from 95% identity to kko:Kkor_1618)

MetaCyc: 70% identical to quinolinate synthase (Escherichia coli K-12 substr. MG1655)
Quinolinate synthase. [EC: 2.5.1.72]

Predicted SEED Role

"Quinolinate synthetase (EC 2.5.1.72)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.5.1.72)

MetaCyc Pathways

• aspartate superpathway (20/25 steps found)
• NAD de novo biosynthesis I (6/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (6/6 steps found)
• NAD de novo biosynthesis III (5/6 steps found)
• nicotine biosynthesis (3/9 steps found)
• superpathway of nicotine biosynthesis (4/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.72

Protein Sequence (353 amino acids)

>B158DRAFT_2453 quinolinate synthetase (EC 2.5.1.72) (Kangiella aquimarina DSM 16071)
MAMNQTVAPIEIDVPFPKPPVELSTDEKEHHRKLIKELLAQHNAVLIAHYYTDPEIQALA
EETGGFVGDSLEMAKFGARHPADTLIIAGVKFMGETAKILSPEKRVLMPTLEATCSLDLG
CPIEPFSEFCDQHPDREVVVYANTSAAVKARADWVVTSSIAVDVLEYLAEQGKKIIWGPD
KHLGRYIQQKTGADMLLWQGACIVHDEFKYKALEQTMALYPEAAVLVHPESPQKIVDLAD
FVGSTSQLIKAAKELPQKQVIVATDKGIFYKMQQAAPEKELIIAPTAGEGATCRSCAHCP
WMKMNVLQLLSQVFEQDDNEVFVDHDLAEKALIPLQKMVNFANDIQANVKSNI