Protein Info for B158DRAFT_2377 in Kangiella aquimarina DSM 16071

Annotation: gamma-glutamyltranspeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00066: gamma-glutamyltransferase
  • amino acids 49 to 569 (521 residues), 639.5 bits, E=1.8e-196
• PF01019: G_glu_transpept
  • amino acids 63 to 571 (509 residues), 618 bits, E=7.5e-190

Best Hits

Swiss-Prot: 49% identical to GGT_PSEUA: Glutathione hydrolase proenzyme (ggt) from Pseudomonas sp. (strain A14)

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 90% identity to kko:Kkor_1697)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

• γ-glutamyl cycle (5/6 steps found)
• glutathione degradation (DUG pathway) (2/2 steps found)
• leukotriene biosynthesis (2/6 steps found)
• peptido-conjugates in tissue regeneration biosynthesis (6/17 steps found)
• hypoglycin biosynthesis (3/14 steps found)

KEGG Metabolic Maps

• Arachidonic acid metabolism
• Cyanoamino acid metabolism
• Glutathione metabolism
• Selenoamino acid metabolism
• Taurine and hypotaurine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.2.2

Use Curated BLAST to search for 2.3.2.2

Protein Sequence (578 amino acids)

>B158DRAFT_2377 gamma-glutamyltranspeptidase (Kangiella aquimarina DSM 16071)
MIRPVLHTLTSLLLTLTVSFSAYASSESKEAPAIIDYQSIHHPVVAEKGMVVSQQYIASR
VGRDILKKGGNAVDAAVATAFALAVVLPRAGNLGGGGFMLIHLAEKDQTVAIDYREMAPA
QAHRNLFLYADGNVDPQKARFSHLSSGVPGTVAGMELALKQYGTMTIKEVIQPAIDLAEN
GFEVTWDLSNNLERRRTRMQNEATKKAFYKPDGSSYQAGEILKQPDLAWSLKQIQKYGAK
AFYQGEIAKRIAADMTQHGGLITLEDLANYKPVVRKPLIGDYRGHQVVTMPPSSSGGVHL
IQMLNILEHFSLKEMGSNSANSIHVMTESMKRAYADRSKHLGDTDFYDVPIDWLTSKDYA
SKLAKTIELDKVTPSSSIEAGTKPKYESPDTTHFSVVDQWGNAVSNTYTLNFSYGSGIVA
EGTGILLNNEMDDFSAKPGTPNAYGLIGGEANAIEPKKRPLSSMTPTMVFKDGKVKLVTG
SPGGSRIITTVLQMVVNVIDHEMNVAEATHTARFHHQWLPDRLFVEPAINTDTRDLLKAK
GYELYDSSTMGSTQSIQVEDYIYGSADPRRPNAEAAGY