Protein Info for B158DRAFT_2201 in Kangiella aquimarina DSM 16071

Annotation: multisubunit sodium/proton antiporter, MrpD subunit (TC 2.A.63.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF10125: NADHdeh_related
  • amino acids 117 to 220 (104 residues), 33.3 bits, E=3.5e-12
• PF00361: Proton_antipo_M
  • amino acids 131 to 424 (294 residues), 214.9 bits, E=1.5e-67

Best Hits

Swiss-Prot: 30% identical to MRPD_BACPE: Na(+)/H(+) antiporter subunit D (mrpD) from Bacillus pseudofirmus (strain OF4)

KEGG orthology group: K05568, multicomponent Na+:H+ antiporter subunit D (inferred from 92% identity to kko:Kkor_0769)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain N (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• Fe(II) oxidation (3/6 steps found)
• NAD(P)/NADPH interconversion (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Protein Sequence (492 amino acids)

>B158DRAFT_2201 multisubunit sodium/proton antiporter, MrpD subunit (TC 2.A.63.1) (Kangiella aquimarina DSM 16071)
MIDHLPILQVIVPLLAAPICLILREAQLVRWFTLIASVFAFVISVLLLQQVQAHGTLIYS
LGGWDAPIGIEYRIDQLNAYLLILVTSISSVALLAAGTSLQKELTERKETYFYVAYLLCL
AGLLGILTTGDAFNVFVFLEISSLASYTLIAMGRDRRSLWASYQYLIMGTIGATFILIGI
GMMYMMTGTLNMYDLAERLPEVQQTKTVFTAFAFFMVGVCLKLALFPLHLWLPNAYAYAP
SIATVFLAATATKVAIYVLLRFIFSVYGFEFSFSHLPLKEILVALGLMGIFAASIVAIYQ
NNIKRLFAYSSVAQIGYMILGLGIGSKTGLVATLLHLFNHALMKGAIFLALAGVVYRVGS
VNIKAFAGLGKQMPWTMGAIVVGGLSLIGVPLTVGFVSKWYLVLALLESNWWPIAILVLV
GSLLAVIYVWRLVEAAYFRPALQDSAPYKEAPLMILIPTWILVLANIYFGIDTSFTVGLS
EQISASLFGVAK