Protein Info for B158DRAFT_2152 in Kangiella aquimarina DSM 16071

Annotation: Predicted metalloendopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 697 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF05649: Peptidase_M13_N" amino acids 65 to 441 (377 residues), 432.3 bits, see alignment E=2.2e-133 PF01431: Peptidase_M13" amino acids 493 to 694 (202 residues), 268.8 bits, see alignment E=3.1e-84

Best Hits

KEGG orthology group: K01415, endothelin-converting enzyme [EC: 3.4.24.71] (inferred from 92% identity to kko:Kkor_0718)

Predicted SEED Role

"Peptidase, M13 family"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.24.71

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (697 amino acids)

>B158DRAFT_2152 Predicted metalloendopeptidase (Kangiella aquimarina DSM 16071)
MKKLLISSVCLAVLAACNSGTDEQKANQEAAKQEVAEQTSNTATQAEQKLVSGIDKAHFD
TSVRPQDDLFRHVNGKWLNEFEIPADKSNYGAFTMLAEQAREDVNAIIEEAANSNAEQGS
DAQKVGDLYQSYMNEELLEELGTKPLQPELEKIAAIENLSDLSEYIAYAQMISEAPFSTY
VYVDAKEPDTYITQMSQNGLGLPSRDFYLKEDEKSEEIRQKYVEHMENMFELAGVKNGAE
KAKTVMEIEMQIAEKHWPKEKLRNPVARYNKMSFEELQNTIPNLDWERWSKTAMLEGIDN
VIVGQPDYFAAVNDMLKEVSIDDWKTYYQWHLISDSARFLNKAIAEESFRFNQGVLSGVE
EQEPRWKRAVNVINGTLGEVVGKIYVEKHFKPEAKERMKELVENLRTAYAQGIKELDWMG
EETKKQALDKLAKFTPKIGYPDKWKDYSALEIKADDLFGNMKRATMVEVKRNREKLGQPI
DRTEWFMTPQTVNAYYNPVMNEIVFPAAILQPPFFNMEADDAVNYGGIGAVIGHEMGHGF
DDSGSQYDGDGKLRNWWTEEDLEEFTKRTDKLVAQYSDFTVLDGVHVNGEFTQGENIGDL
GGLTIAYKAYQISKNGEPAPVIDGMTGDQRVFYGWAQVWRRKYRDEELRKRIDTDPHSPS
EFRANGTVMNMPEFHEAFDVKPGDKMYLKPEERVKIW