Protein Info for B158DRAFT_1950 in Kangiella aquimarina DSM 16071

Annotation: DNA mismatch repair protein MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 586 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 310 (310 residues), 323.8 bits, see alignment E=7.6e-101 PF02518: HATPase_c" amino acids 21 to 77 (57 residues), 36.8 bits, see alignment 9.2e-13 PF13589: HATPase_c_3" amino acids 24 to 115 (92 residues), 48.4 bits, see alignment E=2e-16 PF01119: DNA_mis_repair" amino acids 213 to 329 (117 residues), 127.5 bits, see alignment E=4.2e-41 PF08676: MutL_C" amino acids 420 to 542 (123 residues), 40 bits, see alignment E=6.7e-14

Best Hits

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 84% identity to kko:Kkor_0516)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (586 amino acids)

>B158DRAFT_1950 DNA mismatch repair protein MutL (Kangiella aquimarina DSM 16071)
MPIHKLSPLVANQIAAGEVVERPASVVKELLENAIDAKADRIQIDIERGGTRLIRVTDNG
EGISRDELELALARHATSKIEHSDDLKAIYTLGFRGEALASISSVAKLKLSSRPQAQDMG
WSAIAEGLDMQVKLQPQSLPAGTIVEVRDLFFNTPARQKFLRAERTEFVHIEETVKRIAL
GSPHVAITLRHNSKVIKRVPAAHNHEQHQQRIGSILGASFLREAIKLDSSIESTRLYGWL
SPVDWHQSSSLGQYVFVNGRAVRDRTLNHAIRQAYHDRLPAGRMPAYVLYLELEATQVDV
NVHPTKHEVRFSNGRQVHDFMSRVVEEALLEQSDILENSHDGGNNRETLVYMKPSLSVVQ
SQTKDDPYFTPRQQAGAFAKPTIDEVNERSPAGYVPQQKNHWPQKPKSDLKLAKGDFWLL
HDRLLLQQTEQGINALDLKAFFCQYISDCLQQEWQAGEVKQRLMLFPIRLGIPVDSVNED
FIADWQAAGFDLTLTGPKTLVVRKVPSCISHLDLQQWLQQVVYESVSKSLTVEDLQRELI
ETLPDNWAPQSQTHWLEELAHLPWSESKFCKRYTSEQLLELLMSSQ