Protein Info for B158DRAFT_1811 in Kangiella aquimarina DSM 16071

Annotation: arginine decarboxylase (EC 4.1.1.19)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 9 to 643 (635 residues), 818.9 bits, E=1.5e-250
• PF02784: Orn_Arg_deC_N
  • amino acids 85 to 354 (270 residues), 148.9 bits, E=2.6e-47
• PF17810: Arg_decarb_HB
  • amino acids 378 to 465 (88 residues), 78.1 bits, E=7.6e-26
• PF17944: Arg_decarbox_C
  • amino acids 593 to 642 (50 residues), 55.7 bits, 8.5e-19

Best Hits

Swiss-Prot: 54% identical to SPEA_MARHV: Biosynthetic arginine decarboxylase (speA) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 94% identity to kko:Kkor_1128)

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of arginine and polyamine biosynthesis (12/17 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• superpathway of polyamine biosynthesis II (5/8 steps found)
• spermidine biosynthesis III (2/4 steps found)
• superpathway of polyamine biosynthesis I (4/8 steps found)
• superpathway of putrescine biosynthesis (1/4 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (2/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (3/13 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Protein Sequence (644 amino acids)

>B158DRAFT_1811 arginine decarboxylase (EC 4.1.1.19) (Kangiella aquimarina DSM 16071)
MALEQQDDWSIDKARTHYNLPYWSEGYFDLNEQGNLVVKPDRNRPEFNFELTEICKELQK
KGFQMPALLRFSDILHNRVNSLCEAFNQAIREYEFKGHYTICYPIKVNQQRRVVEEIVQS
QAAINNNNDKQIGLEAGSKPELMAVLALSEHTNSTIVCNGYKDREYIRTALIGTQLGHKV
YIVVEKLTELQLVMEEAESMGVKPTIGVRARLASKGESKWQTSGGDHSKFGLSASQILRL
VETLQEKDQVDIFKLLHFHLGSQITSIRDIQNALKECARFYAELHALGVPVETVDVGGGL
GVDYEGTRSQSHCSINYSLSEYANNVVWAFYDVANENDLPHPNIITESGRALTAHHAVLI
ANVIDSEAPEKVDLEAPSEEAPLVLHNLWESYQEAINTKDNRKLMESFHDAGYLLTEAQG
MFSHQVLSLAERAMAERLHRMILMLVKEKLVPEIQEHQNILDELNEKLASKYFVNFSIFQ
SLPDAWAIDQIFPVMPLLGLNEEPTESVIIQDITCDSDGVLEQYVNGQGITPTIHLPPYK
PGDEYLLGFFMVGAYQEILGDMHNLFGDTHTIDLVLTEIGEIKITGTDYGSGVDEMLEYV
DFDAKSLLESYRRQLKSSNLEQAQQRQYLAELREGIYGYSYLED