Protein Info for B158DRAFT_1734 in Kangiella aquimarina DSM 16071

Annotation: Acyl-CoA dehydrogenases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 20 to 131 (112 residues), 127.2 bits, E=8.1e-41
• PF02770: Acyl-CoA_dh_M
  • amino acids 135 to 226 (92 residues), 83.5 bits, E=1.9e-27
• PF00441: Acyl-CoA_dh_1
  • amino acids 239 to 384 (146 residues), 84.5 bits, E=1.7e-27
• PF08028: Acyl-CoA_dh_2
  • amino acids 253 to 373 (121 residues), 23.5 bits, E=1.2e-08

Best Hits

Swiss-Prot: 70% identical to GCDH_HUMAN: Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) from Homo sapiens

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 97% identity to kko:Kkor_1207)

MetaCyc: 75% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (10/15 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Protein Sequence (392 amino acids)

>B158DRAFT_1734 Acyl-CoA dehydrogenases (Kangiella aquimarina DSM 16071)
MSKALLDHWDDILLLDEQLTEEERMIRDAARDYCQEKLMPRVLEANRHEIFDREIMNELG
ELGLLGSTIDGYGCAGASYVAYGLVAREVERVDSGYRSALSVQSSLVMHPINAYGTEAQK
EKFLPKLASGEWVGCFGLTEPDSGSDPASMKTRAKKVDGGYRLTGSKMWITNSPIADVFI
VWAKDDEGDIRGFILEKGMEGLSAPKIEGKFALRASITGEIVMDNVFVPEENKFPEIKGL
KGPFGCLNVARYGISWGALGAAEFCWHAARQYGLDRKQFNKPLASMQLFQKKLADMQTEI
ALGLQGSLRVGRLIDEKRFKPEMISLVKRNSCGKALEIARMSRDMHGGNGIADEYHVIRH
VMNLEAVNTYEGTHDIHALILGRAQTGLQAFM