Protein Info for B158DRAFT_1697 in Kangiella aquimarina DSM 16071

Annotation: heavy metal efflux pump (cobalt-zinc-cadmium)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 346 to 362 (17 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 395 to 416 (22 residues), see Phobius details amino acids 452 to 471 (20 residues), see Phobius details amino acids 483 to 507 (25 residues), see Phobius details amino acids 536 to 556 (21 residues), see Phobius details amino acids 875 to 894 (20 residues), see Phobius details amino acids 901 to 920 (20 residues), see Phobius details amino acids 927 to 951 (25 residues), see Phobius details amino acids 972 to 992 (21 residues), see Phobius details amino acids 1004 to 1027 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1033 (1033 residues), 1519.5 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1031 (1027 residues), 1061.5 bits, see alignment E=0

Best Hits

Swiss-Prot: 58% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 79% identity to abo:ABO_1377)

MetaCyc: 60% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1035 amino acids)

>B158DRAFT_1697 heavy metal efflux pump (cobalt-zinc-cadmium) (Kangiella aquimarina DSM 16071)
MINAILRLSIERRFLIMILMLAVIGIGIWSYQKLPIDAVPDITNVQVQINTEAPGYSPLE
AEQRITFPVETALYGLPELDYTRSLSRYGLSQVTVVFKEGTDIYHARNLIDERLSAIKSV
LPAGLEPEMGPIATGLGEIFVYTVEAAPEATQENGKPWDAMALREVQDWIIKPQLAQVPG
VVEINTIGGFDKQYHVRPDPQRLLQMGVTMEDVASALRSNNNNRGAGYIEKNGQQLLVRS
PGQLATISEIESVVVGRFGNVPVTIKDVAEVAIGKELRTGAATRDGHETVMGTAMMLIGE
NPQVVAQELAQKLEEIKLSLPKGIEVEAVYNRTSLVDKTIATVQKNLLEGALLVIVVLFL
LLGNIRAALITAAVIPLSMLATITGMVHTGVSANLMSLGALDFGLIVDGAVIIVENCIRR
LSESQQQTGKRLELRERLELVYQATSEVIRPSLFGVAIITVVYIPIFTLTGVEGKMFHPM
AATVVMALLSAMFLSLTFVPAAVALFMGGKISEKESRIIVVSKSFYRPVLEMALRFRWLV
VSAASALIVFSVWLLTTLGSEFIPQLDEGDIALHALRIPGTGLEQSIDMQEVLEERLKDF
PEVDKVYAKIGTPEVATDPMPPSVADNFVILKPRSEWPDPDREKADLVAEMEAAVTQLPG
NKYEFTQPIQMRFNELISGVRADLGIKVFGDDLDQLVITANDILKVLKGIEGSADARVEQ
VTGLPMLSIIPKRMMLARYGLNLNDLQELVAAGIGGEEAGLIYEGDRRFKLVVRLPEAIR
TDIDNLAFLPVPLPDGGFVPLNEVAELALKPAPAQISRENGKRRVVVTANVRDRDLGSFV
EEVKQRINQQVNIPSGYWLDYGGTFEQMESASQRLTIVVPITLLIIIALLVMAFGSLKDS
LIIFTGVPLALTGGVLALWVRDMPLSISAGVGFIALSGVAVLNGLVMVAFIRDLWHQTGD
LTKAVIDGALIRLRPVLMTALVASLGFIPMALNTGTGAEVQRPLATVVIGGIISSTLLTL
IVLPILYQLVHRGKK