Protein Info for B158DRAFT_1687 in Kangiella aquimarina DSM 16071

Annotation: copper-(or silver)-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 778 transmembrane" amino acids 129 to 146 (18 residues), see Phobius details amino acids 158 to 175 (18 residues), see Phobius details amino acids 195 to 214 (20 residues), see Phobius details amino acids 226 to 245 (20 residues), see Phobius details amino acids 376 to 398 (23 residues), see Phobius details amino acids 404 to 427 (24 residues), see Phobius details amino acids 721 to 741 (21 residues), see Phobius details amino acids 747 to 767 (21 residues), see Phobius details PF00403: HMA" amino acids 41 to 97 (57 residues), 64.3 bits, see alignment 2.2e-21 TIGR01511: copper-translocating P-type ATPase" amino acids 175 to 771 (597 residues), 611.7 bits, see alignment E=2.9e-187 TIGR01525: heavy metal translocating P-type ATPase" amino acids 193 to 770 (578 residues), 628.6 bits, see alignment E=2.3e-192 TIGR01494: HAD ATPase, P-type, family IC" amino acids 240 to 751 (512 residues), 290.5 bits, see alignment E=3.7e-90 PF00122: E1-E2_ATPase" amino acids 261 to 441 (181 residues), 191.6 bits, see alignment E=1.8e-60 PF00702: Hydrolase" amino acids 458 to 674 (217 residues), 112.5 bits, see alignment E=7.1e-36

Best Hits

Swiss-Prot: 52% identical to COPA_SALTI: Copper-exporting P-type ATPase (copA) from Salmonella typhi

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 89% identity to kko:Kkor_1304)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (778 amino acids)

>B158DRAFT_1687 copper-(or silver)-translocating P-type ATPase (Kangiella aquimarina DSM 16071)
MSSLNTETGSASCHEGGAATPPHDHHAHHHDQVGNAGLHELIIEGAGCASCVAKIESALK
AVPGVENAEMNFAQRTVSVKGNAEAADLVKAVEKAGYNAKLAAAESEDDALAEKEKADQA
YYKRLMKETWIALSLGGPLMAYALITGEVNVNTTTERVAWLIVGILTFGVLYFSGKHFFV
GAWKSFLNHSANMDTLIALGTGTAWLYSMVVVFFPESVPEQARHVYFEATAIIIGLIDLG
LALELKARGRTSEAIKRLIGLQPKTARVIRDDKELDIAIEQVLMDDMVRVRPGEKIPVDG
DVIEGHTAIDESMLTGEPMPVEKAVGDSVAAGTINKTGSILFKATRVGKDTALAQIINMV
KRAQNSKPPIGRLADVISAYFVPVVMIIAVTSALVWLNFGPDLAVAYAIVSATTVLIIAC
PCALGLATPMSVMVGVGKAAEAGVLIRNGEALQTASKISAMILDKTGTITLGAPKVTDIV
VAGEQDEETILKLAATLESGSEHPLALAIVESAQEKGIETGKVSNFNAIAGHGVMAEVDG
KNLLFGNEKLMRERNIGLSGFVEKAQNLASEAKTPMYFAVNNQLSAIIAVADPIKEDSIA
AIKRLQHNGIRVVMLTGDNRATAKAVAEKAGIKEFFAEVLPEEKSKKVQELQMEGEVVGM
TGDGINDAPALAIANVGFAIGTGTDVAIESADITLMRGSLHGLADAIAVSKATLRNIKQN
LFGAFIYNVAGIPVAAGVLYPLLGMLMNPVIAGAAMAFSSLTVVTNANRLRFFKAQEH