Protein Info for B158DRAFT_1616 in Kangiella aquimarina DSM 16071

Annotation: copper-(or silver)-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 transmembrane" amino acids 102 to 123 (22 residues), see Phobius details amino acids 130 to 147 (18 residues), see Phobius details amino acids 167 to 186 (20 residues), see Phobius details amino acids 198 to 217 (20 residues), see Phobius details amino acids 348 to 371 (24 residues), see Phobius details amino acids 377 to 399 (23 residues), see Phobius details amino acids 693 to 712 (20 residues), see Phobius details amino acids 718 to 739 (22 residues), see Phobius details PF00403: HMA" amino acids 13 to 70 (58 residues), 52.6 bits, see alignment 9.6e-18 TIGR01511: copper-translocating P-type ATPase" amino acids 147 to 743 (597 residues), 639 bits, see alignment E=1.6e-195 TIGR01525: heavy metal translocating P-type ATPase" amino acids 165 to 742 (578 residues), 651.7 bits, see alignment E=2.4e-199 TIGR01494: HAD ATPase, P-type, family IC" amino acids 205 to 711 (507 residues), 302.8 bits, see alignment E=7.1e-94 PF00122: E1-E2_ATPase" amino acids 233 to 413 (181 residues), 203.2 bits, see alignment E=5.2e-64 PF00702: Hydrolase" amino acids 430 to 647 (218 residues), 122.4 bits, see alignment E=6.5e-39

Best Hits

Swiss-Prot: 54% identical to ATCS_SYNE7: Probable copper-transporting ATPase PacS (pacS) from Synechococcus elongatus (strain PCC 7942)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 92% identity to kko:Kkor_1356)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (750 amino acids)

>B158DRAFT_1616 copper-(or silver)-translocating P-type ATPase (Kangiella aquimarina DSM 16071)
MSDHSSHSKTVELNIEGAGCASCVGKIEGALKGVSGVESAEMNFADRTVTVKGTANTDIM
IEAVENAGYQASLIENESESEALEEKEQANQAYYKRLMTKMWIALGVGVPLMAYGLLGGA
MTVTTTNERIAWLIVGLVTLAIMYFSGKHFFTGAWKSFKNHSANMDTLIALGTGTAWVYS
MVVVFFPNSLPEMARHVYFEATAMIIGLINLGLALEVRARGRTSEAIKRLIGLQAKTARV
IRDGDEKDIPIEDVQKDDLVRVRPGEKIPVDGVVTEGNSTLDESMLTGEPMPVEKGEGDE
VSAGTINKSGSIIFKATRVGKDTALAQIIKMVKQAQNSKPPIGRLADVIAAYFVPTVMII
AVISALIWLNFGAQDAIAFAVVSATTVLIIACPCALGLATPMSVMVGVGKAAEAGVLIRN
GESLQTASKITAMVLDKTGTITEGSPKVTDIVGFNDVSQNAALQLAASLETGSEHPLAQA
IVESAKEKDIELKKSSDFNSIAGHGVEGNVDGKHLYFGNEKLMRDQGIDIDHAVDRAQEL
AGEAKTPMYFAIDKKLAAIIAVADPIKEDSIEAIKRLQKANIRVVMLTGDNKATAKAVAS
KVGIDEFFAEVLPEDKVNKVKELQKEGELVGMAGDGINDAPALAQADVGFAIGTGTDVAI
ESADITLMRGSLHGLADAVATSKATLRNIKQNLFGAFIYNVAGIPIAAGLLYPFFGILLS
PVIAGAAMAFSSVTVVTNANRLRFFKPKEH