Protein Info for B158DRAFT_1609 in Kangiella aquimarina DSM 16071

Annotation: putative thymidine phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 TIGR02645: putative thymidine phosphorylase" amino acids 14 to 498 (485 residues), 590 bits, see alignment E=1.6e-181 PF02885: Glycos_trans_3N" amino acids 101 to 161 (61 residues), 48.8 bits, see alignment E=7.2e-17 PF00591: Glycos_transf_3" amino acids 169 to 398 (230 residues), 39.6 bits, see alignment E=7.2e-14 PF07831: PYNP_C" amino acids 431 to 491 (61 residues), 29.9 bits, see alignment E=5.3e-11

Best Hits

Swiss-Prot: 51% identical to TYPH_LEGPH: Putative thymidine phosphorylase (lpg1022) from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

KEGG orthology group: K00758, thymidine phosphorylase [EC: 2.4.2.4] (inferred from 88% identity to kko:Kkor_1364)

Predicted SEED Role

"Thymidine phosphorylase (EC 2.4.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 2.4.2.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.4

Use Curated BLAST to search for 2.4.2.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (504 amino acids)

>B158DRAFT_1609 putative thymidine phosphorylase (Kangiella aquimarina DSM 16071)
MDKTESILPVAIRLGINSRHEPLIFLRSDSPVARSEGFESMSRVLVEVNSKSIIATLLIV
YSDLIQSGFAGLSETAWKRLKLKKGQRIKLSHAPQVDSLAYIRAKAFGHELNKHQLQEIM
RDIVDGHYMDVHLAAFITACANNNMTQDEILYLTQGMVSAGETLTWPGEKIVDKHCVGGL
PGNRTSPIVVSILASKGLTIPKTSSRAITSPAGTADVMETMTKVDLSFNQLKEVVEKNHG
CLAWGGSVSLSPADDILISVEKALDIDFEGQLIASILSKKIAAGSKYVLIDIPVGPTAKL
RSEESAQALAEQLTTVGEKMGLKVKVVLTDGSQPVGFGIGPALEAWDVIGVLKNSSSAPA
DLRERSVLLAGELLEHAGVVNNGDGKDEALRVVESGEAWKTFMQICEAQGGFKYPPVACC
KMAVPAEKSGYIRRVNNRLLSRLAKLAGAPADHASGVYMEAKVGHYLTEGSTLLTIHSEA
PGELEYALDFYNTHKEMIIIEEGL