Protein Info for B158DRAFT_1470 in Kangiella aquimarina DSM 16071

Annotation: glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 10 to 295 (286 residues), 65.5 bits, E=1.7e-22
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 23 to 416 (394 residues), 453.9 bits, E=2.2e-140

Best Hits

Swiss-Prot: 54% identical to PROA_IDILO: Gamma-glutamyl phosphate reductase (proA) from Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 95% identity to kko:Kkor_1498)

MetaCyc: 44% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• L-citrulline biosynthesis (5/8 steps found)
• L-N^δ-acetylornithine biosynthesis (4/7 steps found)
• superpathway of L-citrulline metabolism (7/12 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (428 amino acids)

>B158DRAFT_1470 glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) (Kangiella aquimarina DSM 16071)
MTMQEKSFESQEQQELYEMTMRAKQAAQTLGNLTSSQKNDVLAAMAKRLKANQDQILEAN
KKDIEYAKENDLSDAMVDRLLLDEARVDGMVDALHNVMSLADPVGEMGPSTLRPNGIRVA
KMRIPLGVVLMIYEARPNVAVEAAALTLKSGNVVILRGGKEAWHSNQALIQCWHDALSDC
GLSKEMVCMVPSQSHEAVNHLLQFRDTIDLVIPRGGERLIRAVTDNSKIPVIQHFKGVCH
LYVDKFADLDKAEKLLKDGKVSRPGVCNALESLVIHKDIANEFLKRVNKLGNEFGIQFKA
DKDSAAQLDNATEASADDYHNEYLSLAMSVKQADSYDDAVAHILEHSSSHTEVIVTENID
RGNEFVRRINSSVVMVNASSRFSDGGELGLGAEIGISTSKLHAYGPMGLVQLTTEKYVVT
GQGQAKHY