Protein Info for B158DRAFT_1301 in Kangiella aquimarina DSM 16071

Annotation: Kef-type potassium/proton antiporter, CPA2 family (TC 2.A.37.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 629 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 32 to 51 (20 residues), see Phobius details amino acids 57 to 76 (20 residues), see Phobius details amino acids 88 to 111 (24 residues), see Phobius details amino acids 118 to 138 (21 residues), see Phobius details amino acids 150 to 173 (24 residues), see Phobius details amino acids 193 to 212 (20 residues), see Phobius details amino acids 224 to 242 (19 residues), see Phobius details amino acids 248 to 266 (19 residues), see Phobius details amino acids 277 to 295 (19 residues), see Phobius details amino acids 301 to 324 (24 residues), see Phobius details amino acids 335 to 355 (21 residues), see Phobius details amino acids 366 to 387 (22 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 12 to 383 (372 residues), 199.7 bits, see alignment E=7e-63 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 14 to 294 (281 residues), 243.4 bits, see alignment E=1.6e-76 PF02254: TrkA_N" amino acids 414 to 528 (115 residues), 88.9 bits, see alignment E=3.1e-29

Best Hits

KEGG orthology group: K11747, glutathione-regulated potassium-efflux system protein KefB (inferred from 93% identity to kko:Kkor_0959)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefC" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (629 amino acids)

>B158DRAFT_1301 Kef-type potassium/proton antiporter, CPA2 family (TC 2.A.37.1) (Kangiella aquimarina DSM 16071)
MEMQGALYQTFIFLLAAVIGVTLAKRMGLGSVLGYLGAGIIIGPFALGLVGDDVGDVMHF
AEFGVVMMLFLIGLELEPKKLWKLRVPILGLGGLQVILTTLLITAISVSVIGLHWKMSLA
IGMMLALSSTAIVLQTLSEKGLLRTHGGKSAFSVLLFQDVIVIPMIAIMPLLSTLHVDAT
TSVGHVEELGLQQTFLILGSVIGIILVGRYLVSPIFNWIARTGLREIFIATSLLLVITIT
LVMQKVGLSPALGAFLAGVVLAESQYRHELEVGLDTFKSLLLGLFFITVGASINLDVLIE
YAGVIIGLLVLLLVVKIVVLGVLAAQFKMPLLENLIFTFSLAQGGEFAFVLSTYAAQNGV
LDQNTISILTVVVTLSMLLTPLLIIFAERVLQPRLKKDIEHRDFDEIDDGETPVIVAGYG
RFGQVVSRLLRSQGFNTTLLEYDVMQIELVKKFGTKAFYGDVTNVEILKAAGAETAKLMI
IAVDNQDKCLKVTRLCKEHFPQLKVLARAKGRREAHELRKAGADFVVRETLGSALLLGQE
ALSALGFRHYQAHRAAKTFLHYDNKHLEELSDIWGDDKQYILEAAEKAELLETVLRADQE
ANKVEQRQPWMADWTSEEGAEETKKSEES