Protein Info for B158DRAFT_1069 in Kangiella aquimarina DSM 16071

Annotation: succinyldiaminopimelate desuccinylase (EC 3.5.1.18)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01246: succinyl-diaminopimelate desuccinylase
  • amino acids 6 to 374 (369 residues), 540.5 bits, E=2e-166
• TIGR01910: peptidase, ArgE/DapE family
  • amino acids 6 to 366 (361 residues), 226.6 bits, E=5.9e-71
• PF01546: Peptidase_M20
  • amino acids 65 to 371 (307 residues), 153.5 bits, E=7.4e-49
• PF07687: M20_dimer
  • amino acids 177 to 283 (107 residues), 94 bits, E=5.3e-31

Best Hits

Swiss-Prot: 66% identical to DAPE_VIBVU: Succinyl-diaminopimelate desuccinylase (dapE) from Vibrio vulnificus (strain CMCP6)

KEGG orthology group: K01439, succinyl-diaminopimelate desuccinylase [EC: 3.5.1.18] (inferred from 92% identity to kko:Kkor_1924)

MetaCyc: 58% identical to succinyl-diaminopimelate desuccinylase (Escherichia coli K-12 substr. MG1655)
Succinyl-diaminopimelate desuccinylase. [EC: 3.5.1.18]

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate desuccinylase (EC 3.5.1.18)" in subsystem Arginine Biosynthesis extended or Lysine Biosynthesis DAP Pathway (EC 3.5.1.18)

MetaCyc Pathways

• L-lysine biosynthesis I (9/9 steps found)
• aspartate superpathway (20/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (13/18 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.18

Use Curated BLAST to search for 3.5.1.18

Protein Sequence (381 amino acids)

>B158DRAFT_1069 succinyldiaminopimelate desuccinylase (EC 3.5.1.18) (Kangiella aquimarina DSM 16071)
MSETLALSKDLINRPSVTPEDAGCQQMMMQYLEALGFKNEIMNFEDTSNFWSLRHGRTEG
PVFVFAGHTDVVPAGPLENWHTPPFEATEKEGYLYGRGASDMKSSLAAMLVATKRFVKDY
PEHIGSIGFLITSDEEGPFINGTVRVVEELMKRNQPLDYCVVGEPSSSEQFGDVIKNGRR
GSLTGFLTIKGTQGHVAYPHLADNAIHKSLKALDELAHTEWDQGNQFFPATSFQIAIIKA
GTAGNVIPGEKYVEFNFRYSTETTHQELQQKVVAVLDKYNLEYDLNWKLNGEPFLTDHGH
LLTAARNAIRAVCQINTAPLTTGGTSDGRFIAKTGAEIVEIGPVNKTIHQINECVKIEDL
DKLTEVYYQILVELLATPKTL