Protein Info for B158DRAFT_0973 in Kangiella aquimarina DSM 16071

Annotation: type I secretion outer membrane protein, TolC family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR01844: type I secretion outer membrane protein, TolC family" amino acids 25 to 455 (431 residues), 311.7 bits, see alignment E=4e-97 PF02321: OEP" amino acids 28 to 222 (195 residues), 126 bits, see alignment E=7.9e-41 amino acids 246 to 440 (195 residues), 113.8 bits, see alignment E=4.5e-37

Best Hits

KEGG orthology group: K12340, outer membrane channel protein TolC (inferred from 86% identity to kko:Kkor_2013)

Predicted SEED Role

"Type I secretion outer membrane protein, TolC precursor" in subsystem Multidrug Resistance Efflux Pumps or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (457 amino acids)

>B158DRAFT_0973 type I secretion outer membrane protein, TolC family (Kangiella aquimarina DSM 16071)
MKPTTTIKLVTLAVLSLSGFSSQANTDLLEVYQDALKNDPQYKISEANLRATEQGVRISR
SSLLPQVSASATKGMSDYDYSGQGLDGSPSDPFSNEVDSTTYRVQLSQSLFDWSRWVALE
QAELRVRAAELSHAASLQDLMTRTAQAYFQTLSRKEVLEATRSEKEALQQQLDLTREQFE
SGLSSATDFLDAQANFDQAQVSELVAENEYTNAVEALREITGQYYSELEAAGNEVTLTPP
TPANIDDWMRAAREANLSLKAKQFDVRVAREEVKRNKSGHYPTADLNVTYSDQETETDRF
FPIQNIDQNTLNMQDGYQAGITVTIPLFSGFRTSAETEQSKQNYLRTTHELDQSDRLVQK
NARMAYTNLQTSIKSFEANKRAYESSINSLESTQEGYQAGTRNIVDVLIATRSAYSAQRN
MIRAKYDYLISSLQLKAAAGTLTEKDIEAVNNLLEQF