Protein Info for B158DRAFT_0803 in Kangiella aquimarina DSM 16071

Annotation: Aminopeptidase N

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 948 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF17900: Peptidase_M1_N" amino acids 87 to 264 (178 residues), 116.6 bits, see alignment E=2.3e-37 PF01433: Peptidase_M1" amino acids 306 to 519 (214 residues), 235.2 bits, see alignment E=1e-73 PF11838: ERAP1_C" amino acids 606 to 925 (320 residues), 132 bits, see alignment E=5e-42

Best Hits

KEGG orthology group: K01263, cytosol alanyl aminopeptidase [EC: 3.4.11.14] (inferred from 84% identity to kko:Kkor_2199)

Predicted SEED Role

"Membrane alanine aminopeptidase N (EC 3.4.11.2)" (EC 3.4.11.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.2

Use Curated BLAST to search for 3.4.11.14 or 3.4.11.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (948 amino acids)

>B158DRAFT_0803 Aminopeptidase N (Kangiella aquimarina DSM 16071)
MSKAYLATICFLATILVTACQPDDQQQQDDSQKTQVSEHETLVKPIANSDTESDTLSEES
AELDAAAFESDYPAEIPTGRLPGLARPTMYWLELTIDPDQPNFSGKVSINVELDTPSQHL
WLHGRDITAQSVSAKLADGKIINGSYEEVDPTGVAKLTFNNPLPAGKFDLTIQYQAPFNE
SLEGLYRVNDGGLNYAFTQFEATSARLAFPGFDEPAFKVPFNYTITVRSEHKAFTSTPAV
SETDLGNGWKRIVYARSKPMPTYLVAFAVGDFDVVEWKAIPPTKVREREIPLRGIATKGK
GKKLTYALENTKDILNGLEEYFQIPYPYAKLDIVAVPDFNFGAMENVGLITYREQLLLFD
DTISLDQKRAYINVHAHELAHQWFGNLVTPEWWDDIWLNEAFATWMAHVSNNNVYPEQKF
RQTLLERSLGAMRQDSLIHARQIRQPIASNHDIQSAFDSITYSKGGGVLSMIESFMTPEE
FRAGIQHYMKKHEFGVATANDFITAIGEKSTKVPLETIRSAFNSFLEQPGIPYLEVELSC
NNEQAMVNLTQSRYLPIGSKGSSQQSWEVPACIEYAIDGNQHQYCSVIDSAEYSFEIPEA
GCPEYVMPNSEGAGYYRFSMSGENWQKLLDNKDQLSTEDMISVNDSFSAAINAGKLSFLD
LIEIAPQIIDSESPRVAMAPTDLLSFAYDKVVSSEEDKQILASLNRDLYQLKLEELGLVT
RKEDSVDQVQMRNALVAFLAQKGQDKNLRHYLTKMATDYTGYQSDSALHPDKADSNVINT
AMAVAVEELGVPFAEHLLTQLNESNDGTVRGRMLIGLGSVEDEEFATELRELILSESLRD
NEIYYILMGQMESQELQDAMWDWFKQNIDGVKSRIPPFGQNRLPVVGNMFCSEQKKKDFM
AFFEPIVQELPGAPRSFDQTVENIELCIAKVEHHSEGVMQYINQQTAQ