Protein Info for B158DRAFT_0782 in Kangiella aquimarina DSM 16071

Annotation: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00521: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
  • amino acids 3 to 394 (392 residues), 470.3 bits, E=2.6e-145
• PF02441: Flavoprotein
  • amino acids 6 to 179 (174 residues), 127.7 bits, E=3.4e-41
• PF04127: DFP
  • amino acids 185 to 366 (182 residues), 239.2 bits, E=3e-75

Best Hits

Swiss-Prot: 59% identical to COABC_VIBPA: Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 90% identity to kko:Kkor_2221)

MetaCyc: 56% identical to fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase (Escherichia coli K-12 substr. MG1655)
Phosphopantothenate--cysteine ligase. [EC: 6.3.2.5]; Phosphopantothenoylcysteine decarboxylase. [EC: 6.3.2.5, 4.1.1.36]

Predicted SEED Role

"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (8/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• coenzyme A biosynthesis I (bacteria) (4/4 steps found)
• coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)
• coenzyme A biosynthesis III (archaea) (3/4 steps found)
• taurine biosynthesis II (1/4 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.36 or 6.3.2.5

Protein Sequence (399 amino acids)

>B158DRAFT_0782 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic (Kangiella aquimarina DSM 16071)
MKLQGKKVLLGITGGIAAYKSAELCRNLKKAGAEVRVVMTKGAQAFITPLTLQALSGNPV
HHDLLDPNAEAAMGHIELARWSDFVVVAPASADFMARLNAGMADDLLTTLCLATASPIAV
APAMNQQMWANPATQHNVQQLMLKGIEIWGPDEGDQACGDVGPGRMLEPSDLLNRIDDHF
NDKPLKGQHWLITAGPTVEPIDPVRYLANRSSGKMGFAIAEAAARAGAEVTLVTGPVNLT
VSGSIKRIDVQTAQQMFEAVQSQFKGVDTFVACAAVSDYRPKVAAQQKLKKQSDDGLTIE
LTQNPDILRWAAEQNTAFCVGFAAETNNIEEYAEAKMTKKGINVICANDVSRKDIGFSSD
NNEVSVYYKKDGALQVQQLGPALKSVIAHQLVNFLPGIK