Protein Info for B158DRAFT_0585 in Kangiella aquimarina DSM 16071
Annotation: Short-chain alcohol dehydrogenase of unknown specificity
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 58% identical to YDFG_ECOL6: NADP-dependent 3-hydroxy acid dehydrogenase YdfG (ydfG) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG orthology group: K00540, [EC: 1.-.-.-] (inferred from 93% identity to kko:Kkor_2433)MetaCyc: 57% identical to 3-hydroxy acid dehydrogenase YdfG (Escherichia coli K-12 substr. MG1655)
RXN-16000 [EC: 1.1.1.381]; RXN-8974 [EC: 1.1.1.381, 1.1.1.298]; Serine 3-dehydrogenase. [EC: 1.1.1.381, 1.1.1.298, 1.1.1.276]
Predicted SEED Role
"3-hydroxypropionate dehydrogenase (EC 1.1.1.298)" (EC 1.1.1.298)
MetaCyc Pathways
- L-threonine degradation III (to methylglyoxal) (2/3 steps found)
- β-alanine degradation III (1/2 steps found)
- uracil degradation III (3/5 steps found)
- aminopropanol phosphate biosynthesis II (2/4 steps found)
- 3-hydroxypropanoate cycle (6/13 steps found)
- glyoxylate assimilation (6/13 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (9/18 steps found)
- superpathway of L-threonine metabolism (7/18 steps found)
- superpathway of the 3-hydroxypropanoate cycle (7/18 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Carotenoid biosynthesis - General
- Insect hormone biosynthesis
- Nucleotide sugars metabolism
- Porphyrin and chlorophyll metabolism
- Puromycin biosynthesis
- Trinitrotoluene degradation
- alpha-Linolenic acid metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.-.-.-
Use Curated BLAST to search for 1.-.-.- or 1.1.1.276 or 1.1.1.298 or 1.1.1.381
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (260 amino acids)
>B158DRAFT_0585 Short-chain alcohol dehydrogenase of unknown specificity (Kangiella aquimarina DSM 16071) MSDLKDKTVMVTGASSGFGLACAKSFAQKGCKVIAAARRKERLDDLKQELKQELGEDRVF VLPLDVTSEEQVNSMFDAIPEEYSKIDILVNNAGLALGLEPAHQADLTDWNRMVDTNIKG LYLMTRKILPGMVERKSGHIINIGSIAGNYAYPGGNAYGATKAFVKQFSRNLRADLLGTQ VRVTNIEPGLAETEFSLVRFHGDKDKADNVYKGANPLTAEDIAESVLWAAEQPQHVNINS IELMPTSQAWAALAIDKVLG