Protein Info for B158DRAFT_0545 in Kangiella aquimarina DSM 16071

Annotation: glycine dehydrogenase (decarboxylating)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02347: GDC-P
  • amino acids 23 to 445 (423 residues), 597.9 bits, E=1.7e-183
  • amino acids 455 to 737 (283 residues), 39.5 bits, E=5.1e-14
• TIGR00461: glycine dehydrogenase
  • amino acids 24 to 951 (928 residues), 1476.5 bits, E=0
• PF21478: GcvP2_C
  • amino acids 781 to 902 (122 residues), 198.2 bits, E=5.1e-63

Best Hits

Swiss-Prot: 63% identical to GCSP_CHRVO: Glycine dehydrogenase (decarboxylating) (gcvP) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 66% identity to amc:MADE_00863)

MetaCyc: 61% identical to glycine decarboxylase (Escherichia coli K-12 substr. MG1655)
Glycine dehydrogenase (decarboxylating). [EC: 1.4.1.27, 1.4.4.2]

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

• folate transformations III (E. coli) (8/9 steps found)
• folate transformations II (plants) (9/11 steps found)
• glycine biosynthesis II (3/3 steps found)
• glycine cleavage (3/3 steps found)
• glycine degradation (3/3 steps found)
• photorespiration II (6/10 steps found)
• photorespiration I (5/9 steps found)
• photorespiration III (5/9 steps found)
• reductive glycine pathway of autotrophic CO₂ fixation (5/9 steps found)
• folate transformations I (7/13 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.27 or 1.4.4.2

Protein Sequence (961 amino acids)

>B158DRAFT_0545 glycine dehydrogenase (decarboxylating) (Kangiella aquimarina DSM 16071)
MADTLSLKGAPLQQLQQSDDFIRRHLGPREDEIQEMLQELNLSSLDDLVDKAVPHKIQID
APLAVEESRSETETLKYLKSLADKNVIAKSYIGMGYYDTITPTVILRNVLENPGWYTAYT
PYQPEIAQGRLEAILNFQQMTMDLTGMELASASLLDEATAAAEAMALAKRSSKNKKSNSF
FVDENVFPQTLDVVKTRAEHYGWDIVVGPVSEATEHDVFGALLQYTDVNGQVTDLEPIIS
KLHDNKAIACVGADIMSLVLLKAPGEMGADVVFGSAQRFGVPMGFGGPHAAFFATRDAFK
RSLPGRIIGVSVDTRGNQAMRMAMQTREQHIRREKATSNICTAQVLLANIAGFYAVYHGK
KGLTTIANRIHRYATIVAKALQNAGLELVNDSWFDTVTFKAKDVDTVQARAKAALINLRY
NGDKVSFSIDEAKNQADIEELIEVLTGEKTDVFALDSEAKSSIPASLERTTDFLTHPTFK
KYYSETDMLRYLKRLENKDFSLAHGMIPLGSCTMKLNATSEMIPVTWPQFANIHPFAPEE
QTVGYIEMIKELEADLVEITGYDFVSMQPNSGAQGEYAGLLAIKKYFESIGEDHRNICLI
PSSAHGTNPASAQMAGMKVVIVKCDDKGNVDVEDLEAKAVELKDNLAALMVTYPSTHGVF
EEEIKHICQIIHDNGGQVYMDGANMNAQVGISKPGEIGSDVSHLNLHKTFAIPHGGGGPG
MGPIGVKKHLAPFVSGHAVRKVHSVDARDGAVSAAPYGSGMILPISWAYIKMLGREGLRK
STEVALLNANYLKNKLAPHYPVLYMGRNDKVAHECIIDLRQIKAETGISEVDFAKRLMDY
GFHAPTMSFPVAGTFMIEPTESESKYELDRFIDAMISIRQEVEKVRSGEWEADNNPLKNA
PHTQADVRHWDKPYSIAEAVYPSESTIDAKFWPTVNRIDDVYGDRNLICSCPSIESYQDQ
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