Protein Info for B158DRAFT_0509 in Kangiella aquimarina DSM 16071

Annotation: diguanylate cyclase (GGDEF) domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1516 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 791 to 810 (20 residues), see Phobius details PF07494: Reg_prop" amino acids 37 to 59 (23 residues), 21.9 bits, see alignment (E = 7.1e-08) amino acids 310 to 331 (22 residues), 23.4 bits, see alignment (E = 2.3e-08) PF07495: Y_Y_Y" amino acids 716 to 781 (66 residues), 77.9 bits, see alignment (E = 2.3e-25) PF08447: PAS_3" amino acids 872 to 937 (66 residues), 55.5 bits, see alignment (E = 3.1e-18) TIGR00229: PAS domain S-box protein" amino acids 957 to 1073 (117 residues), 59.1 bits, see alignment 4.8e-20 PF08448: PAS_4" amino acids 958 to 1067 (110 residues), 38.2 bits, see alignment 8.3e-13 PF00989: PAS" amino acids 958 to 1063 (106 residues), 46.1 bits, see alignment 2.5e-15 PF13426: PAS_9" amino acids 962 to 1064 (103 residues), 56.4 bits, see alignment 1.8e-18 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 1074 to 1236 (163 residues), 130.2 bits, see alignment E=6e-42 PF00990: GGDEF" amino acids 1077 to 1233 (157 residues), 157.5 bits, see alignment E=1.4e-49 PF00563: EAL" amino acids 1255 to 1489 (235 residues), 249.4 bits, see alignment E=1.8e-77

Best Hits

KEGG orthology group: None (inferred from 86% identity to kko:Kkor_2484)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1516 amino acids)

>B158DRAFT_0509 diguanylate cyclase (GGDEF) domain (Kangiella aquimarina DSM 16071)
MVTRFLFLFCLIGTIFLNQQTQANQQLVDAIGIEDQLSQSVITAIVEDPQGFLWIGTEDG
LNRYDGYQIKVFQKQNSNLSHTTIHDLMVADNGDIWIATENGLNIFQQQTGKIINFHHNP
LEPFTLANDFVTDLSKDEKGGVWLATYNGPSYYDPAIEGFKTYPIMLSRRVTATVSELRK
IYVDSKQRVWAVTTRGELAQFNPTSEQFFIINSTTGGQLGAIADIEETPDGNIWLVSYQQ
GVIEYNPEKSEFVSLSYEELGLRDSKLQASTIFFDSNRNLWIGTVKEGLYSVNNETGRSN
HYRYGRPGSIGSNTINALYEDSNGILWVGTSAYLNKINPNAILFNHNYFQPDLLDSLAAD
TTFSLHITADDVLLVGSDGHGITMMDARDPLDLKKLAIIDPPPLNGKSINYIGPASSGKV
WVMTFDEIWLLNLKTRELQRVFENESYTAELLTARYLDGNLWVGTTEGLWRLDQNNRIDR
YRVIDADFHRNNRINSILPSKDRQYLWIGTESGVHQFDIQTSSFKNLNQLIKEVPEEAND
VVLSLALDQFERLWIGTFGNGLVVIDLTRQVATTINSTTSGIHDSIYSMELDGNKYIWAG
TGRGLFRVSPNDFSLTQFTLAEDQPILEFNTGASTHDRQGNLYFGGINGIINFRAEAYQP
DEVPPTPVITEIMINNGPVLIGDEHKKRLAKPANLAKEVTFFPEDTSVSFVFSGLNYADP
KNNRYRYMLEGYDNEWIETDAKARRVTYTNLQPGDYRFLVKASNKDGVWSEVPAELKVHV
KTSGWLSPSAFTLYGFILGLIILAFSYLIWARVRERRMAALQLTQSEERLKLSLWGSGDE
LWDWQIPSGALHLSNEWPYDFPRDGVRSGYSMANSNIHPNDLPYVRQSLNAHLADKSMHY
ESTYRISDEKGGWIWVLDRGKVVSRDDNQKPLRMAGTLKNITELKNTEQQLSMIVKSFDN
ISDGVWILDENFHYIAVNKAFTKITGFEESEVLGKLMKVSALHKITDEEFRELREELADK
GFWYGELVAKRKDNSTYPIEINIDVVLDNDGNVINYVGVFSDITFRKQAEKELRRLATVD
QLTDLKNRTSFRNHFEDLIAHSERGDQHALLFIDLDNFKRINDSLGHGIGDELLIYVAKI
LQEITSEQHGVVARLGGDEFTVLLQDVDTWNKPAKIAQAILDEFAKPLPLSTAEVVVSPS
IGIVMYPENGLSAEELLKNADTAMYYAKKKGKNTYQFYTRQMNEQAKLRITLEGELRQAI
EKDEFVMFYQPKVSLQTGKITGMEALVRWRNPRRGLVLPNEFIPLAEEAGFIIPISQRVI
EKTCLQIRDWQNRGIFHGKVAVNLSAVQFYHENLWETVKNALHLAKIEPDALEFEITEGM
VMEDLTQSIQQMRTLREMGISLALDDFGVGYSSLGNLKDFPIDTLKIDRTFVWDLEDSDR
DRNLVASIVTLAHNLDIKVVAEGVENRNQVDALRDMGCEEIQGFIFSRPVPPWDIETMLN
IKDFDLDEFITQNESD