Protein Info for B158DRAFT_0391 in Kangiella aquimarina DSM 16071

Annotation: glucosamine--fructose-6-phosphate aminotransferase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 609 (608 residues), 863.3 bits, E=4.9e-264
• PF13230: GATase_4
  • amino acids 33 to 141 (109 residues), 24.9 bits, E=1.9e-09
• PF13522: GATase_6
  • amino acids 66 to 184 (119 residues), 74.9 bits, E=1.3e-24
• PF13537: GATase_7
  • amino acids 80 to 198 (119 residues), 62.3 bits, E=8.8e-21
• PF01380: SIS
  • amino acids 291 to 418 (128 residues), 102 bits, E=4.5e-33
  • amino acids 462 to 591 (130 residues), 83.1 bits, E=3.3e-27

Best Hits

Swiss-Prot: 65% identical to GLMS_SHEON: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 95% identity to kko:Kkor_2625)

MetaCyc: 62% identical to L-glutamine--D-fructose-6-phosphate aminotransferase (Escherichia coli K-12 substr. MG1655)
Glutamine--fructose-6-phosphate transaminase (isomerizing). [EC: 2.6.1.16]

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• UDP-N-acetyl-D-glucosamine biosynthesis I (4/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (2/6 steps found)
• O-antigen building blocks biosynthesis (E. coli) (5/11 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (1/6 steps found)
• chitin biosynthesis (3/9 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (6/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (609 amino acids)

>B158DRAFT_0391 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) (Kangiella aquimarina DSM 16071)
MCGIVGAIAQRDVSQILVEGLKRLEYRGYDSAGLAIYNDNEIQRLRRLGKVSELQQALND
TPLPGGLGIAHTRWATHGEPSERNAHPHMSEDNIALVHNGIIENHDELRDELKAKGYTFS
SDTDTEVMAHCLHEELKTSSSLLEALQKTTKKLEGAYGTVAIDANDPNKMVVARSGSPLV
IGKGIGEYFVASDQLALLPVTRDFIYLEEGEVAEVRRDGVTILDSNGNQVEREFETSDIQ
HDAVDKGRYRHFMLKEIFEQPQVVNDTLEGRLVNHKIIIETLGANANKVFADTRAVQIIA
CGTSYHAALVAKYWIEDYLNIPCLVEIASEYRYRETAVLPNSLFITISQSGETADTLAAL
KKAKEQGYLGTLTVCNSPASSMVRESDFTLLTRAGTEIGVASTKAFTAQLVSLMLLMVTI
GKAQGMDEAKEKSIVDALEHLPNEIQSALEQAEAIEDLSEAFAEKHHTLFLGRGQQYPIA
MEAALKLKEISYIHAEAYAAGELKHGPLALIDKEMPIVVVAPKDNLLEKLKSNIEEVRSR
GGQLFVFADESANIQSSDGITVFPIKSQYAITAPMVYTIPMQLLSYYVAVIKGTDVDQPR
NLAKSVTVE