Protein Info for B158DRAFT_0062 in Kangiella aquimarina DSM 16071

Annotation: pantoate--beta-alanine ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 281 TIGR00018: pantoate--beta-alanine ligase" amino acids 1 to 279 (279 residues), 349.2 bits, see alignment E=1.3e-108 PF02569: Pantoate_ligase" amino acids 3 to 277 (275 residues), 371.1 bits, see alignment E=1.4e-115 TIGR00125: cytidyltransferase-like domain" amino acids 26 to 73 (48 residues), 39.6 bits, see alignment 4.5e-14

Best Hits

Swiss-Prot: 53% identical to PANC_MARHV: Pantothenate synthetase (panC) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K01918, pantoate--beta-alanine ligase [EC: 6.3.2.1] (inferred from 88% identity to kko:Kkor_0350)

MetaCyc: 49% identical to pantothenate synthetase (Escherichia coli K-12 substr. MG1655)
Pantoate--beta-alanine ligase. [EC: 6.3.2.1]

Predicted SEED Role

"Pantoate--beta-alanine ligase (EC 6.3.2.1)" in subsystem Coenzyme A Biosynthesis (EC 6.3.2.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (281 amino acids)

>B158DRAFT_0062 pantoate--beta-alanine ligase (Kangiella aquimarina DSM 16071)
MIVVNSVQTLRRLIQTHRDMGHRIGFVPTMGNLHAGHLSLVETAKKHADIVVVSIFVNPT
QFGPNEDFDAYPRTFEQDQALLEQEGADIVFAPEVAEVYPNWPNLTKVQVAELGNNHCGA
SRPGHFDGVTTVVSKLFNMVRPDCAVFGQKDFQQLAIIKRMTSDLNFDIEIIGAPIVREV
NGLAMSSRNGYLSNEQKEHASFIYQTLNWLKQQIDNGERDYRALENAAAQRLAEQDFKPD
YVNIARQDNLELAENEDRELVILIAAFMGKVRLIDNVTLSL