Protein Info for Atu6011 in Agrobacterium fabrum C58

Annotation: tryptophan 2-monooxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 755 PF02027: RolB_RolC" amino acids 11 to 195 (185 residues), 133.6 bits, see alignment E=1.3e-42 PF13450: NAD_binding_8" amino acids 241 to 298 (58 residues), 35 bits, see alignment 2.8e-12 PF01593: Amino_oxidase" amino acids 246 to 729 (484 residues), 355.8 bits, see alignment E=9.9e-110

Best Hits

Swiss-Prot: 93% identical to TR2M_RHIRD: Tryptophan 2-monooxygenase (tms1) from Rhizobium radiobacter

KEGG orthology group: K00466, tryptophan 2-monooxygenase [EC: 1.13.12.3] (inferred from 100% identity to atu:Atu6011)

MetaCyc: 93% identical to tryptophan 2'-monooxygenase (Agrobacterium tumefaciens)
Tryptophan 2-monooxygenase. [EC: 1.13.12.3]

Predicted SEED Role

"Tryptophan 2-monooxygenase (EC 1.13.12.3)" in subsystem Aromatic amino acid degradation (EC 1.13.12.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.12.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CL10 at UniProt or InterPro

Protein Sequence (755 amino acids)

>Atu6011 tryptophan 2-monooxygenase (Agrobacterium fabrum C58)
MSASALLDNQCDHFSTKMVDLIMVDKADELDRRVSDAFSEREASRGRRITQISGECSAGL
ACKRLADGRFPEISAGEKVAALSAYIYVGKEILGRILESEPWARARVSGLVAIDLAPFCM
DFSEAQLLQTLFLLSGKRCASSDLSHFVAISISKTARSRTLQMPPYEKGTTKRVTGFTLT
LEEAVPFDMVAYGRNLMLKASAGSFPTIDLLYDYRSFFDQCSDSGRIGFFPEDVPKPKVA
IIGAGISGLVVASELLHAGVDDVTIYEASDRVGGKLWSHAFKDAPSVVAEMGAMRFPPAA
SCLFFFLERYGLSSMRPFPNPGTVDTNLVYQGLRYMWKAGQQPPKLFHRVYSGWRAFLKD
GFHEGDIVLASPVAITQALKSGDIRRAHDSWQTWLNRFGRESFSSAIERIFLGTHPPGGE
TWSFPHDWDLFKLMGIGSGGFGPVFESGFIEILRLVINGYEENQRMCSEGISELPRRIAT
QVVNGVSVSQRIRHVQVRAIEKEKTKIKIRLKSGISELYDKVVVTSGLANIQLRHCLTCD
TTIFRAPVNQAVDNSHMTGSSKLFLLTERKFWLDHILPSCVLMDGIAKAVYCLDYEPQDP
NGKGLVLISYTWEDDSHKLLAVPDKKERFCLLRDAISRSFPAFAQHLVPACADYDQNVVQ
HDWLTDENAGGAFKLNRRGEDFYSEELFFQALDMTNDTGVYLAGCSCSFTGGWVEGAIQT
ACNAVCAIIHNCGGILAKDNPLEHSWKRYNYRNRN