Protein Info for Atu5539 in Agrobacterium fabrum C58

Annotation: HlyD family secretion protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF16576: HlyD_D23" amino acids 46 to 239 (194 residues), 38.7 bits, see alignment E=1e-13 TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 46 to 227 (182 residues), 105.6 bits, see alignment E=1.3e-34 PF13533: Biotin_lipoyl_2" amino acids 48 to 95 (48 residues), 38.4 bits, see alignment 1.2e-13 PF13437: HlyD_3" amino acids 157 to 240 (84 residues), 31.7 bits, see alignment E=3.2e-11

Best Hits

Swiss-Prot: 38% identical to AAEA_YERPY: p-hydroxybenzoic acid efflux pump subunit AaeA (aaeA) from Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

KEGG orthology group: None (inferred from 100% identity to atu:Atu5539)

Predicted SEED Role

"HlyD family secretion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7D2T8 at UniProt or InterPro

Protein Sequence (291 amino acids)

>Atu5539 HlyD family secretion protein (Agrobacterium fabrum C58)
MKNLVFISGRVLLTLSMSSCAAVMGWHLWSFHIGTPWTRDAHVRADIVRLAPDISGPVTE
VLVSDNALVEKDAPLFRIEKDRFELALREAEAQVTGAKAGTDAAKVDFERYQRLASKEAA
SVRERQHAETQMYQAEAAYQSALVARDLAKLNLERTTVRAPASGAITNFSLRKGNYVLAG
NAVGVLVEKESVYVAGYFEETKLPRIHIGDRVKIDIMGEPESAIGHVAGVAAGIEDRERS
DTAGSLASVAPTFSWVRLAQRIPVRIEIDHVPNNVRLIAGRTATIAIEQSK