Protein Info for Atu5377 in Agrobacterium fabrum C58

Annotation: two component sensor kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 TIGR00229: PAS domain S-box protein" amino acids 18 to 139 (122 residues), 58.7 bits, see alignment E=3.2e-20 amino acids 141 to 268 (128 residues), 48.9 bits, see alignment E=3.4e-17 PF00989: PAS" amino acids 21 to 111 (91 residues), 34.1 bits, see alignment E=1.1e-11 amino acids 145 to 260 (116 residues), 36.2 bits, see alignment E=2.4e-12 PF13188: PAS_8" amino acids 23 to 80 (58 residues), 15.1 bits, see alignment 7.9e-06 amino acids 147 to 188 (42 residues), 26.3 bits, see alignment 2.5e-09 PF08448: PAS_4" amino acids 27 to 133 (107 residues), 37.2 bits, see alignment E=1.3e-12 amino acids 150 to 264 (115 residues), 41 bits, see alignment E=9.3e-14 PF13426: PAS_9" amino acids 35 to 131 (97 residues), 39.7 bits, see alignment E=2.3e-13 amino acids 155 to 262 (108 residues), 48.3 bits, see alignment E=5e-16 PF07536: HWE_HK" amino acids 276 to 340 (65 residues), 30.5 bits, see alignment E=2.3e-10 PF07568: HisKA_2" amino acids 276 to 347 (72 residues), 67.3 bits, see alignment E=4.6e-22 PF13581: HATPase_c_2" amino acids 362 to 431 (70 residues), 33.8 bits, see alignment E=1.4e-11 PF02518: HATPase_c" amino acids 373 to 459 (87 residues), 33.3 bits, see alignment E=2.5e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu5377)

Predicted SEED Role

"sensory transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CLA6 at UniProt or InterPro

Protein Sequence (466 amino acids)

>Atu5377 two component sensor kinase (Agrobacterium fabrum C58)
MNDNIIFSGVRTAVPTKQHMEDYEDFFENGAVALHLVGEDGTILRANRAELDLLGFTAEE
YIGRPISQFHADSDTIREILARLSGGEKLNRFPARLRAKDGSIRYVEITSSVQFRDGKFL
NTRCFTIDVTDTVQLRRQLARKEQEMRQILEALPAAVYTTDAQGKITYYNRAATELSGRE
PVVGQDEWCVTYRLFTPDGQPLPHDQCPMAIALREKRAVRGVEAIAQRPDGTMVPFLPFP
TPMFDEDGELIGAINMLVDISDRKTAETNQKVFLDELNHRVKNNMAMLYGLINSAARESR
SDEARRVLGDAAQRVGAMAAAQQTLYMEKDRTRVNAREFLQAVCSSARLAFSKEVALHID
VDAVQLPNDVTMPLALVLNELLTNAAKHGCDDAGKCDVWITLSHHDGEFVLTVRDSGSGY
NFEATGKRSSGTGLVSGLVRQLRGSFSVAPGPGAMCTIRFIDNKLG