Protein Info for Atu5165 in Agrobacterium fabrum C58

Annotation: type IV secretion protein AvhB4

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 757 signal peptide" amino acids 1 to 15 (15 residues), see Phobius details TIGR00929: type IV secretion/conjugal transfer ATPase, VirB4 family" amino acids 1 to 753 (753 residues), 790.3 bits, see alignment E=1.1e-241 PF03135: CagE_TrbE_VirB" amino acids 142 to 344 (203 residues), 172.3 bits, see alignment E=1.4e-54 PF19044: P-loop_TraG" amino acids 583 to 666 (84 residues), 36.1 bits, see alignment E=3.1e-13

Best Hits

Swiss-Prot: 63% identical to VIRB4_BARQU: Type IV secretion system protein virB4 (virB4) from Bartonella quintana (strain Toulouse)

KEGG orthology group: K03199, type IV secretion system protein VirB4 (inferred from 100% identity to atu:Atu5165)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7D3R9 at UniProt or InterPro

Protein Sequence (757 amino acids)

>Atu5165 type IV secretion protein AvhB4 (Agrobacterium fabrum C58)
MVMVALAGVSFETADLLDINALHRDLNTLYRNIADERLAIWTHLIRRRDSDYPGGTFATP
FSASLNEKYRERMAREHLFRNDLYLTVLWSPARSPADKAGKLLSYLRRSKRLDTELDEEA
LKELKDKVVIVMAGLRSFEPRLLSLYEQEGMLFSEPSEVLHQLVGGRRERVPLTEGRVAS
AIYSDRVIIGRETIEIRHEAESRFAGMLSFKEYPARTRTGMLDGVLNSPFELILSQSFCF
VSKADARVIMGRKQNQLVSSGDKAASQIDELDDAMDDLESNRFVLGEHHLTLSVFATTLK
ELTDNLAKVRASLTNGGAVVAREDLGLEAAWWAQLPGNFRYRARSGAISSKNFAALSPFH
SYPIGQKDGNEWGPAVALLKTASGSPYYFNLHYGDLGNTFMCGPSGAGKTVIVNFMLSQL
EKHDPHVVFFDKDRGADLYVRAAGGTYLPLKNGVPTGCAPLKALNLTPENKVFLARWIGK
LVGSGARELTVTELRDISGAIDGLADLPAERRTIGALRAFLNNTDPEGIAARLRRWEEGG
PLGWVFDNVIEDIGFGDFGGSGKFIGYDMTDFLDNEEIRIPLMAYLFHRVEQVIDGRRII
IVIDEFWKALQDEGFRDLAQNKLKTIRKQNGLMLFATQSPRDALNSPIAHTIIEQCPTQI
FLPNSRGNHADYVDGFKLTEREYELIARELSVESRRFVLKQGHNSVVAELDLNGFDDELA
ILSGRTANVELLDAIRAEVGDDVENWLPIFQQRRSAS